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Metformin hydrochloride CAS#1115-70-4

CAS Number: 1115-70-4

Chemical Formula: C4H12ClN5

Synonyms:

1,1-dimethyl-biguanidhydrochloride;diabefagos

diformin;dimethylbiguanidehydrochloride

Dimethyldiguanidinehydrochloride

Appearance: White powder

HS Code:29252900

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Metformin hydrochloride CAS#1115-70-4

Metformin hydrochloride is a biguanide oral hypoglycemic drug, also known as metformin hydrochloride, Glucophage, and Medicon. Its hypoglycemic effect is weaker than that of phenformin. Its main function is to reduce the secretion of glucagon in A cells and promote the conversion of glucose into glycogen. It has the characteristic of not stimulating pancreatic β-cells to secrete insulin.

Parameters

Melting point	223-226 °C(lit.)
density	1.36[at 20℃]
vapor pressure	0.001Pa at 25℃
Fp	9℃
storage temp.	2-8°C
solubility	Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride
pka	12.4[at 20 ℃]
form	Powder
color	White
Water Solubility	Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
λmax	233nm(H2O)(lit.)
Merck	145938
BCS Class	3
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
InChIKey	OETHQSJEHLVLGH-UHFFFAOYSA-N
LogP	-3.5 at 20℃
CAS DataBase Reference	1115-70-4(CAS DataBase Reference)
Safety Information
Hazard Codes	Xn,T,F
Risk Statements	22-36/38-39/23/24/25-23/24/25-11
Safety Statements	26-36-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS	DU1800000
HS Code	29252900
Hazardous Substances Data	1115-70-4(Hazardous Substances Data)
Toxicity	LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin)

Product Application of Metformin hydrochloride CAS#1115-70-4

This product is a hypoglycemic drug. This product can reduce fasting and postprandial hyperglycemia in patients with type 2 diabetes, and HbAlc can be reduced by 1% to 2%. The mechanism of this product in lowering blood sugar may be: ① Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization. ② Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc. ③ Inhibit hepatic gluconeogenesis and reduce hepatic glucose output. ④ Inhibit intestinal wall cells from taking up glucose.

Function and indication: For mild diabetes

Metformin hydrochloride is an antidiabetic agent that reduces blood glucose levels and increases insulin sensitivity. Its metabolism (including inhibition of hepatic gluconeogenesis) is activated through the LKB1-AMPK (AMP-activated protein kinase) pathway.

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