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Dimethyl sulfoxide CAS#67-68-5
CAS Number: 67-68-5
Chemical Formula: C2H6OS
Synonyms:
sulfinylbis (methane)
DMSO
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Appearance: Transperant Liquid
Dimethyl sulfoxide CAS#67-68-5
First synthesized in 1866 by Alexander Zaytsev in the Russian Empire, dimethyl sulfoxide is an organosulfur compound. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water.
Dimethyl sulfoxide Chemical Properties |
Melting point | 18.4 °C |
Boiling point | 189 °C(lit.) |
density | 1.100 g/mL at 20 °C |
vapor density | 2.7 (vs air) |
vapor pressure | 0.42 mm Hg ( 20 °C) |
refractive index | n |
FEMA | 3875 | METHYLSULFINYLMETHANE |
Fp | 192 °F |
storage temp. | Store at +5°C to +30°C. |
solubility | H2O: miscible (completely) |
pka | 35(at 25℃) |
form | liquid (temperature dependent) |
color | clear colorless |
Relative polarity | 0.444 |
Odor | Mild garlic odor |
Appearance | colorless liquid |
Odor Type | alliaceous |
biological source | synthetic |
explosive limit | 1.8-63.0%(V) |
Water Solubility | Soluble in water, methanol, acetone, ether, benzene, chloroform. |
FreezingPoint | 18.4℃ |
Sensitive | Hygroscopic |
λmax | λ: 285 nm Amax: ≤0.20 |
Merck | 14,3259 |
JECFA Number | 507 |
BRN | 506008 |
Dielectric constant | 41.9（55℃） |
Stability: | Stable. Incompatible with a very wide range of materials, including acid chlorides, strong acids, strong oxidizing agents, strong reducing agents, phosphorus halides, moisture, copper wool + trichloroacetic acid. Reacts violently with a number of materials - consult a full data sheet before use. Hygroscopic. |
Cosmetics Ingredients Functions | SOLVENT |
InChIKey | IAZDPXIOMUYVGZ-UHFFFAOYSA-N |
LogP | -1.35 |
Surface tension | 42.179mN/m at 298.15K |
CAS DataBase Reference | 67-68-5(CAS DataBase Reference) |
NIST Chemistry Reference | Dimethyl sulfoxide(67-68-5) |
EPA Substance Registry System | Dimethyl sulfoxide (67-68-5) |
Absorption | passes test |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 24/25-37/39-26-36-23 |
RIDADR | NA 1993 / PGIII |
WGK Germany | 1 |
RTECS | PV6210000 |
F | 3 |
Autoignition Temperature | 215 °C |
TSCA | TSCA listed |
HazardClass | CBL |
HS Code | 29309070 |
Hazardous Substances Data | 67-68-5(Hazardous Substances Data) |
Toxicity | LD50 orally in rats: 17.9 ml/kg (Bartsch) |
Product Application Of Dimethyl sulfoxide CAS#67-68-5
Dimethyl sulfoxide is a highly polar substance that is aprotic, therefore lacking acidic and basic properties. It has exceptional solvent properties for both organic and inorganic components, which are derived from its capacity to associate with both ionic species and neutral molecules that are either polar or polarizable. Dimethyl sulfoxide enhances the topical penetration of drug sowing to its ability to displace bound water from the stratumcorneum;this is accompanied by the extraction of lipids and configurational changes of proteins.
the solvent is diluted. Increases in drug penetration have been reported with dimethyl sulfoxide concentrations as low as 15%,but significant increases in permeability generally require concentrations higher than 60–80%. Furthermore, while low molecular weight substances can penetrate quickly into the deep layers of the skin, the appreciable transport of molecules with a molecular weight of more than 3000 is difficult.
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