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Cimetidine CAS#51481-61-9

CAS Number: 51481-61-9

Chemical Formula: C10H16N6S

Synonyms:

TAGAMET

Cimetidine (base and/or unspecified salts)

SKF-92334

Appearance: White solid

HS Code:29339900

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Cimetidine CAS#51481-61-9

Cimetidine is an H2 receptor antagonist, which can significantly inhibit gastric acid secretion caused by stimulation of food, histamine or pentagastrin, and reduce its acidity. This product has a preventive and protective effect on corrosive gastritis caused by chemical stimulation, and also has a significant effect on stress gastric ulcer and upper gastrointestinal bleeding. This product has an anti-androgen effect and has a certain value in the treatment of hirsutism. This product can weaken the activity of immunosuppressive cells, enhance immune response, thereby inhibiting tumor metastasis and prolonging survival. It is clinically used to treat duodenal ulcer, gastric ulcer, upper gastrointestinal bleeding, etc.

Parameters

Melting point	139-144°C
Boiling point	476.2±55.0 °C(Predicted)
density	1.2583 (rough estimate)
refractive index	1.5700 (estimate)
storage temp.	2-8°C
solubility	Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids.
form	Solid
pka	pKa 6.80 (Uncertain)
color	White to Off-White
Water Solubility	0.5 g/100 mL at 20 ºC
Merck	142279
InChIKey	AQIXAKUUQRKLND-UHFFFAOYSA-N
CAS DataBase Reference	51481-61-9(CAS DataBase Reference)
NIST Chemistry Reference	Cimetidine(51481-61-9)
IARC	3 (Vol. 50) 1990
EPA Substance Registry System	Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- (51481-61-9)
Safety Information
Hazard Codes	T,Xn
Risk Statements	60-42/43-36/37/38-20/22
Safety Statements	53-26-36/37/39-45-36-22
WGK Germany	3
RTECS	MF0035500
HS Code	29339900
Hazardous Substances Data	51481-61-9(Hazardous Substances Data)
Toxicity	LD50 in mice, rats (mg/kg): 2600, 5000 orally; 150, 106 i.v.; 470, 650 i.p. (Brimblecombe)

Product Application of Cimetidine CAS#51481-61-9

Cimetidine, which was launched in 1975, is the first selective H2 receptor antagonist used to treat peptic ulcers. It mainly inhibits gastric acid secretion and reduces its acidity. It has a preventive and protective effect on corrosive gastritis caused by chemical stimulation, and also has obvious therapeutic effects on stress gastric ulcers and upper gastrointestinal bleeding.

Histamine H2 receptor antagonist. It can inhibit gastric acid secretion caused by histamine stimulation, and can also inhibit gastric acid secretion induced by food, pentagastrin, caffeine and insulin, and can also inhibit basal gastric acid secretion. Used for gastric and duodenal ulcers, peptic esophagitis, Zollinger-Ellison syndrome

Used to treat peptic ulcers

Histamine receptor antagonist of H2; I1 imidazoline receptor agonist; anti-ulcer agent. It prevents cancer cell metastasis by inhibiting the expression of selectins on the surface of endothelial cells, thereby blocking the adhesion of tumor cells.

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