Panthenol CAS#16485-10-2

CAS Number: 16485-10-2
Chemical Formula: C9H19NO4
Synonyms:

DL-PANTHENOL
DL-N-PANTOYL-E-PROPANOLAMINE
2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(+-)-Butanamide

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Panthenol CAS#16485-10-2

Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.
Panthenol is a multi-functional active ingredient that would be useful in most skin care formulations. Its efficacy has been substantiated in numerous peer-reviewed journals. The biologically active form of Panthenol, D-panthenol (EU), is the stable alcohol analogue of vitamin B5, pantothenic acid (EU), and is quickly converted to vitamin B5 (pantothenate) in the body. Pantothenic acid is present in all living cells and acts as an essential nutritional component due to its role in the formation of acetyl-co-enzyme A in the early stages of metabolism. The main role of acetyl-co-enzyme A is to provide activated acetic acid into the citric acid cycle (Krebs Cycle). This produces carbon dioxide, water, and energy. Co-enzyme A also transfers to other molecules such as Nacetyl-glucosamine (EU) and acetylcholine (EU) to help in the production of steroids and the synthesis of fatty acids. Coenzyme A also helps the body detoxify foreign substances.

Panthenol

Panthenol Chemical Properties

Melting point	66-69 °C (lit.)
alpha	0°(c=5, H2O)
Boiling point	118-120 °C(Press: 0.02 Torr)
density	1.166±0.06 g/cm3(Predicted)
vapor pressure	0.004Pa at 25℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	13.03±0.20(Predicted)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water, ethanol, ether, chloroform, and propylene glycol.
Sensitive	Hygroscopic
Merck	14,2947
BRN	1724945
Cosmetics Ingredients Functions	HAIR CONDITIONING ANTISTATIC SKIN CONDITIONING
InChIKey	SNPLKNRPJHDVJA-UHFFFAOYSA-N
LogP	-1.02 at 22℃
CAS DataBase Reference	16485-10-2(CAS DataBase Reference)
EPA Substance Registry System	Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl- (16485-10-2)

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-48-41-37/38-20/21/22
Safety Statements	26-37-45-36/37/39-22
WGK Germany	3
RTECS	ES4316500
F	3
TSCA	TSCA listed
HS Code	29362400
Toxicity	mouse,LD50,intraperitoneal,10100mg/kg (10100mg/kg),Farmaco, Edizione Scientifica. Vol. 14, Pg. 43, 1959.

Product Application of Panthenol CAS#16485-10-2

Panthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium.
Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. The vitamin ingredient Panthenol is valued in skin and hair care applications for its moisturizing properties. It has anti-inflammatory effects and soothes irritated and sensitive skin. For hair care application it is known for its humectant properties and its ability to improve the resistance of hair to mechanical stress.

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