Polyethylene-polypropylene glycol CAS#9003-11-6

CAS Number: 9003-11-6
Chemical Formula: (C3H6O.C2H4O)x
Synonyms:

BLOCK COPOLYMER OF POLYETHYLENE AND POLYPROPYLENE GLYCOL
POLOXAMER 184 NF
Polypropylene-polyethylene glycol: (Pluronic L-81)

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Polyethylene-polypropylene glycol CAS#9003-11-6

Pluronic® F-127 is a nonionic detergent widely used to solubilize hydrophobic molecules such as cell-permeable AM esters of Fluo-4, Fluorica-8 calcium indicators, and Di-4-ANEPS, Di-8-ANEPS potentiometric probes and facilitate their loading into cells. We offer Pluronic® F-127 as a ready-to-use 10% solution in H2O.

Below is a typical procedure for loading AM esters of ion indicators and other dyes into cells using a 10% solution of Pluronic® F-127 in water. Cell loading conditions may vary depending on the cell types or compounds loaded.

Polyethylene-polypropylene glycol Chemical Properties

Melting point	57-61 °C
Boiling point	>200 °C(lit.)
bulk density	1050kg/m3
density	1.095 g/mL at 25 °C
vapor density	>1 (vs air)
vapor pressure	<0.3 mm Hg ( 20 °C)
refractive index	n20/D 1.466
Fp	>230 °F
storage temp.	2-8°C
solubility	H2O: at <70 °Csoluble
form	solution
color	APHA: ≤120, 50/50 in CH3OH
PH	5.0-7.5 (100g/L in H2O)
PH Range	5.0 - 7.5
biological source	synthetic
Water Solubility	Miscible with water.
λmax	λ: 260 nm Amax: ≤0.3 λ: 280 nm Amax: ≤0..2
Merck	13,7644
Hydrophilic-Lipophilic Balance (HLB)	18 - 23
Cosmetics Ingredients Functions	SURFACTANT - CLEANSING SURFACTANT - HYDROTROPE CLEANSING SOLVENT HUMECTANT EMULSION STABILISING BINDING SURFACTANT - EMULSIFYING VISCOSITY CONTROLLING
InChI	1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChIKey	RVGRUAULSDPKGF-UHFFFAOYSA-N
SMILES	O2C(C2)C.O1CC1
LogP	-1.293 (est)
EPA Substance Registry System	Poloxalene (9003-11-6)

Safety Information

Hazard Codes	T
Risk Statements	21-23/24/25-25-36/37/38
Safety Statements	23-24/25-45-36/37/39-26
WGK Germany	3
RTECS	TP6164333
TSCA	TSCA listed
HS Code	39059100
Storage Class	11 - Combustible Solids
Hazardous Substances Data	9003-11-6(Hazardous Substances Data)
Toxicity	LD50 oral in rabbit: 35gm/kg

Product Application Of Polyethylene-polypropylene glycol CAS#9003-11-6

Polyethylene-polypropylene glycol is nonionic polyoxyethylene–polyoxypropylene copolymers used primarily in pharmaceutical formulations as emulsifying or solubilizing agents.The polyoxyethylene segment is hydrophilic while the polyoxypropylene segment is hydrophobic. All of the Polyethylene-polypropylene glycol is chemically similar in composition, differing only in the relative amounts of propylene and ethylene oxides added during manufacture. Their physical and surface-active properties vary over a wide range and a number of different types are commercially available;
Polyethylene-polypropylene glycol is used as emulsifying agents in intravenous fat emulsions, and as solubilizing and stabilizing agents to maintain the clarity of elixirs and syrups. Polyethylene-polypropylene glycol may also be used as wetting agents; in ointments, suppository bases, and gels; and as tablet binders and coatings.
Poloxamer 188 has also been used as an emulsifying agent for fluorocarbons used as artificial blood substitutes, and in the preparation of solid-dispersion systems. More recently,Polyethylene-polypropylene glycol has found use in drug-delivery systems.
Therapeutically, poloxamer 188 is administered orally as a wetting agent and stool lubricant in the treatment of constipation; it is usually used in combination with a laxative such as danthron. Polyethylene-polypropylene glycol may also be used therapeutically as wetting agents in eye-drop formulations, in the treatment of kidney stones, and as skin-wound cleansers.
Poloxamer 338 and 407 are used in solutions for contact lens care.

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