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Omeprazole CAS#73590-58-6

CAS Number: 73590-58-6

Chemical Formula: C17H19N3O3S

Synonyms:

elgam

ceprandal

belmazol

Appearance: White solid

HS Code:29333990

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Omeprazole CAS#73590-58-6

Omeprazole is a proton pump inhibitor used to treat diseases such as peptic ulcer and gastroesophageal reflux disease (GERD). It can specifically act on the site of the proton pump in the gastric parietal cells and convert it into the active form of sulfenamide. It then irreversibly binds to the sulfhydryl group of the proton pump through a disulfide bond to form a complex of sulfenamide and the proton pump (H+-K+-ATPase), thereby inhibiting the activity of the enzyme, preventing the H+ in the parietal cells from being transported to the gastric cavity, blocking the last step of gastric acid secretion, and greatly reducing the amount of gastric acid in gastric juice. Therefore, this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons (such as basal gastric acid secretion and gastric acid secretion caused by histamine, pentagastrin and stimulation of the vagus nerve, including gastric acid secretion caused by dibutyl cyclic adenosine monophosphate that cannot be inhibited by H2 receptor blockers). This is related to the irreversibility of the inhibitory effect of this product on the proton pump. The acid secretion can only be restored after a new proton pump is formed.

Parameters

Melting point	156°C
Boiling point	600.0±60.0 °C(Predicted)
density	1.332 g/cm3
Fp	9℃
storage temp.	2-8°C
solubility	H2O: 0.5 mg/mL
form	solid
pka	pKa 4.14/8.9(H2O,t =25,I=0.025) (Uncertain)
color	white
Water Solubility	Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).
Merck	146845
BCS Class	2
Stability:	Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.
InChIKey	SUBDBMMJDZJVOS-UHFFFAOYSA-N
CAS DataBase Reference	73590-58-6(CAS DataBase Reference)
EPA Substance Registry System	1H-Benzimidazole, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- (73590-58-6)
Safety Information
Hazard Codes	Xi,T,F
Risk Statements	36/37/38-39/23/24/25-23/24/25-11
Safety Statements	26-36-37/39-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	2
RTECS	DD9087000
HS Code	29333990
Hazardous Substances Data	73590-58-6(Hazardous Substances Data)
Toxicity	LD50 in mice, rats (g/kg): 0.08, >0.05 i.v.; >4, >4 orally (Ekman)

Product Application of Omeprazole CAS#73590-58-6

1. Used for gastric and duodenal ulcers, stress ulcers, etc.

2. Used for reflux esophagitis and gastrinoma.

3. This injection can also be used for: ① Gastrointestinal bleeding, such as peptic ulcer bleeding, anastomotic ulcer bleeding, etc., and prevention of upper gastrointestinal bleeding caused by severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery. ② Acute gastric mucosal damage caused by stress or non-steroidal anti-inflammatory drugs. ③ After general anesthesia or major surgery and in comatose patients, to prevent gastric acid reflux and aspiration pneumonia.

4. Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp). The pharmacological effects, synthetic routes, uses, precautions, etc. of omeprazole are compiled by the Eastern Editor of Chemicalbook. (2016-01-22)

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