Gomisin A CAS#58546-54-6

CAS Number: 58546-54-6
Chemical Formula:C23H28O7
Synonyms:

SCHIZANDROL B
BESIGOMISIN
2,3,13-tetramethoxy-l-stereoisomer

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Gomisin A CAS#58546-54-6

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .

Gomisin A Chemical Properties

Melting point	88.5°C
Boiling point	454.79°C (rough estimate)
density	1.1772 (rough estimate)
refractive index	1.5300 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	powder to crystal
pka	14.58±0.40(Predicted)
color	White to Light yellow
biological source	Schisandra chinensis
InChI	1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1
InChIKey	ZWRRJEICIPUPHZ-MYODQAERSA-N
SMILES	C[C@]1([H])[C@@](C)(O)CC2=C(C(OC)=C(OC)C(OC)=C2)C3=C(OC)C4=C(OCO4)C=C3C1
LogP	4.770 (est)

Safety Information

Safety Statements	24/25
WGK Germany	WGK 3
HS Code	29329990
Storage Class	11 - Combustible Solidsb

Product Application of Gomisin A CAS#58546-54-6

Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.

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