N,N-Dimethylformamide CAS#68-12-2

Products Description of N,N-Dimethylformamide CAS#68-12-2

Dimethylformamide (DMF) is a flammable, colorless liquid with a fishy odor , featuring a molecular weight of 73.11, boiling point of 153°C, freezing point of -61°C, flash point of 58°C, and vapor pressure of 3 mmHg at 20°C . It is soluble in water and organic solvents, with hazards including flammability (explosive limits: LEL 2.2%, UEL 15.2%), toxicity, carcinogenicity, mutagenicity, and skin irritation. Widely used as a solvent in manufacturing acrylic fibers, pharmaceuticals, dyes, petroleum products, and organic chemicals, it also serves as a gasoline additive and in electronics applications.

Parameters

Melting point	-61 °C (lit.)
alpha	0.94 º
Boiling point	153 °C (lit.)
density	0.944 g/mL (lit.)
vapor density	2.5 (vs air)
vapor pressure	2.7 mm Hg ( 20 °C)
refractive index	n20/D 1.430(lit.)
Fp	136 °F
storage temp.	Store at +5°C to +30°C.
solubility	water: miscible
pka	-0.44±0.70(Predicted)
form	liquid
color	APHA: ≤15
PH	7 (200g/l, H2O, 20℃)
Odor	Faint, ammonia-like odor detectable at 100 ppm
Relative polarity	0.386
Odor Threshold	1.8ppm
explosive limit	2.2-16%(V)
Water Solubility	soluble
λmax	λ: 270 nm Amax: 1.00 λ: 275 nm Amax: 0.30 λ: 295 nm Amax: 0.10 λ: 310 nm Amax: 0.05 λ: 340-400 nm Amax: 0.01
Sensitive	Hygroscopic
Merck	14,3243
BRN	605365
Exposure limits	NIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted).
Dielectric constant	36.710000000000001
InChIKey	ZMXDDKWLCZADIW-UHFFFAOYSA-N
LogP	-1.010
Surface tension	35.20mN/m at 298.15K
Surface tension	37.1mN/m at 20°C
CAS DataBase  Reference	68-12-2(CAS DataBase Reference)
NIST Chemistry  Reference	Formamide, N,N-dimethyl-(68-12-2)
IARC	2A (Vol. 47, 71, 115) 2018
EPA Substance  Registry System	N,N-Dimethylformamide (68-12-2)

Safety Information

Hazard Codes	T
Risk Statements	61-20/21-36
Safety Statements	53-45
RIDADR	UN 2265 3/PG 3
OEB	A
OEL	TWA: 10 ppm (30 mg/m3) [skin]
WGK Germany	1
RTECS	LQ2100000
F	3-10
Autoignition  Temperature	445 °C
Hazard Note	Toxic
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29241990
Hazardous  Substances Data	68-12-2(Hazardous Substances Data)
Toxicity	LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch)
IDLA	500 ppm

Product Application of  N,N-Dimethylformamide CAS#68-12-2

The principal applications of N,N-dimethylformamide are as a solvent and as an extractant, particularly for salts and compounds with high molecular mass. This role is consistent with its interesting combination of physical and chemical properties: low molecular mass, high dielectric constant, electron-donor characteristics, and ability to form complexes. The use of DMF as a component in synthesis is of relatively minor significance, at least commercially. N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It may be employed as solvent medium for the various organic reduction reactions.

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