Ethyl acetate CAS#141-78-6

CAS Number: 141-78-6
Chemical Formula: C4H8O2
Synonyms:

AKOS BBS-00004223
METHYLATED SPIRIT
METHYLATED SPIRIT INDUSTRIAL

Appearance: Transperant Liquid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Ethyl acetate CAS#141-78-6

Ethyl acetate (systematically, ethyl ethanoate, commonly abbreviated EtOAc or EA) is the organic compound with the formula CH3COOCH2CH3. This colorless liquid has a characteristic sweet smell (similar to pear drops) and is used in glues, nail polish removers, decaffeinating tea and coffee, and cigarettes (see list of additives in cigarettes). Ethyl acetate is the ester of ethanol and acetic acid; it is manufactured on a large scale for use as a solvent. The combined annual production in 1985 of Japan, North America, and Europe was about 400,000 tons. In 2004, an estimated 1.3M tons were produced worldwide.

Ethyl acetate Chemical Properties

Melting point	−84 °C(lit.)
Boiling point	76.5-77.5 °C(lit.)
density	0.902 g/mL at 25 °C(lit.)
vapor density	3 (20 °C, vs air)
vapor pressure	73 mm Hg ( 20 °C)
refractive index	n20/D 1.3720(lit.)
FEMA	2414 \| ETHYL ACETATE
Fp	26 °F
storage temp.	Store at +2°C to +25°C.
solubility	Miscible with ethanol, acetone, diethyl ether and benzene.
pka	16-18(at 25℃)
form	Liquid
color	APHA: ≤10
Specific Gravity	0.902 (20/20℃)
Relative polarity	0.228
Odor	Pleasant fruity odor detectable at 7 to 50 ppm (mean = 18 ppm)
Odor Threshold	0.87ppm
Odor Type	ethereal
biological source	synthetic
explosive limit	2.2-11.5%, 38°F
Water Solubility	80 g/L (20 ºC)
λmax	λ: 256 nm Amax: ≤1.00 λ: 275 nm Amax: ≤0.05 λ: 300 nm Amax: ≤0.03 λ: 325-400 nm Amax: ≤0.005
Merck	14,3757
JECFA Number	27
BRN	506104
Henry's Law Constant	0.39 at 5.00 °C, 0.58 at 10.00 °C, 0.85 at 15.00 °C, 1.17 at 20.00 °C, 1.58 at 25.00 °C (column stripping-UV, Kutsuna et al., 2005)
Exposure limits	TLV-TWA 400 ppm (～1400 mg/m3) (ACGIH, MSHA, and OSHA); IDLH 10,000 ppm (NIOSH).
Dielectric constant	23.0（Ambient）
Stability:	Stable. Incompatible with various plastics, strong oxidizing agents. Highly flammable. Vapour/air mixtures explosive. May be moisture sensitive.
Cosmetics Ingredients Functions	SOLVENT PERFUMING
InChI	1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
InChIKey	XEKOWRVHYACXOJ-UHFFFAOYSA-N
SMILES	CCOC(C)=O
LogP	0.68-0.73 at 20-25℃
Surface tension	23.93mN/m at 293.15K
CAS DataBase Reference	141-78-6(CAS DataBase Reference)
NIST Chemistry Reference	Ethyl acetate(141-78-6)
EPA Substance Registry System	Ethyl acetate (141-78-6)

Safety Information

Hazard Codes	F,Xi,Xn,T
Risk Statements	11-36-66-67-20/21/22-10-39/23/24/25-23/24/25-68/20/21/22
Safety Statements	16-26-33-36/37-45-7-25
RIDADR	UN 1173 3/PG 2
OEB	A
OEL	TWA: 400 ppm (1400 mg/m3)
WGK Germany	1
RTECS	AH5425000
F	1
Autoignition Temperature	427 °C
TSCA	TSCA listed
HS Code	2915 31 00
HazardClass	3
PackingGroup	II
Storage Class	3 - Flammable liquids
Hazard Classifications	Eye Irrit. 2 Flam. Liq. 2 STOT SE 3
Hazardous Substances Data	141-78-6(Hazardous Substances Data)
Toxicity	LD50 orally in rats: 11.3 ml/kg (Smyth)
IDLA	2,000 ppm [10% LEL]

Product Application Of Ethyl acetate CAS#141-78-6

In pharmaceutical preparations, ethyl acetate is primarily used as a solvent, although it has also been used as a flavoring agent. As a solvent, it is included in topical solutions and gels, and in edible printing inks used for tablets.
Ethyl acetate has also been shown to increase the solubility of chlortalidone and to modify the polymorphic crystal forms obtained for piroxicam pivalate, mefenamic acid, and fluconazole,and has been used in the formulation of microspheres. Ethyl acetate has been used as a solvent in the preparation of a liposomal amphotericin B dry powder inhaler formulation.(9) Its use as a chemical enhancer for the transdermal iontophoresis of insulin has been investigated.
In food applications, ethyl acetate is mainly used as a flavoring agent. It is also used in artificial fruit essence and as an extraction solvent in food processing.

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