N,N-Dimethylformamide CAS#68-12-2

Dimethylformamide is a flammable, colorlessliquid with a fishy, unpleasant, amine-like odor at relativelylow concentrations. The odor threshold is 0.47100 ppm.Molecular weight= 73.11; Specific gravity (H2O:1)= 0.95;Boiling point = 153℃; Freezing/Melting point = 261℃;Vapor pressure= 3 mmHg at 20℃; Flash point = 58℃;Autoignition temperature= 444.5℃. Explosive limits are:LEL = 2.2%; UEL= 15.2% at 100℃. Hazard Identification(based on NFPA-704 M Rating System): Health 2,Flammability 2, Reactivity 0. Soluble in water.Potential Exposure: Tumorigen,Mutagen; Reproductive Effector; Human Data; Hormone,Primary Irritant. DMFA is used as a solvent for liquids,gases, and as a gasoline additive. Dimethylformamide haspowerful solvent properties for a wide range of organiccompounds. Because of its physical properties, this chemical has been used when solvents with a slow rate of evaporation are required. It finds particular usage in themanufacture of polyacrylic fibers, butadiene, purified acetylene, pharmaceuticals, dyes, petroleum products, and otherorganic chemicals.

The principal applications of N,N-dimethylformamide are as a solvent and as an extractant, particularly for salts and compounds with high molecular mass. This role is consistent with its interesting combination of physical and chemical properties: low molecular mass, high dielectric constant, electron-donor characteristics, and ability to form complexes. The use of DMF as a component in synthesis is of relatively minor significance, at least commercially. N,N-Dimethylformamide (anhydrous) has been used as solvent for the synthesis of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic drug) and fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It may be employed as solvent medium for the various organic reduction reactions.