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Sulfadiazine CAS#68-35-9

CAS Number: 68-35-9

Chemical Formula: C10H10N4O2S

Synonyms:

Sulfadiazine,(S)

-AMino-N-2-pyriMidinylbenzenesulfonaMide

4-amino-N-2-pyrimidinyl

Appearance: White powder

HS Code:29335990

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Sulfadiazine CAS#68-35-9
Sulfadiazine is a sulfonamide anti-infective drug commonly used in clinical practice in my country. It is also called sulfadiazine and diazine. The molecular structure of sulfadiazine is similar to para-aminobenzoic acid (PABA). It can compete with PABA on dihydrofolate synthase in bacteria, thereby preventing PABA from being used as a raw material to synthesize folic acid required by bacteria, reducing the amount of metabolically active tetrahydrofolate, which is an essential substance for bacteria to synthesize purine, thymidine and deoxyribonucleic acid (DNA), thus inhibiting the growth and reproduction of bacteria. Sulfadiazine has an inhibitory effect on sensitive bacteria such as hemolytic streptococci, staphylococci, meningococci, pneumococci, gonococci, Escherichia coli, Shigella dysenteriae, and microorganisms such as Chlamydia trachomatis, actinomycetes, Plasmodium, Nocardia asteroides, and Toxoplasma.

Parameters

Melting point	253 °C (dec.) (lit.)
Boiling point	512.6±52.0 °C(Predicted)
density	1.3780 (rough estimate)
refractive index	1.6440 (estimate)
storage temp.	2-8°C
solubility	Soluble in dimethyl sulfoxide.
pk	pKa 2.21(H2O t = 25 I = 0.5 (NaCl)) (Uncertain)
form	powder
color	white
Water Solubility	67.13mg/L(25 ºC)
Merck	148903
BRN	6733588
BCS Class	45750
CAS DataBase Reference	68-35-9(CAS DataBase Reference)
NIST Chemistry Reference	Sulfadiazine(68-35-9)
EPA Substance Registry System	Benzenesulfonamide, 4-amino-N-2-pyrimidinyl- (68-35-9)
Safety Information
Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-42/43-43-42
Safety Statements	26-36
RIDADR	3249
WGK Germany	3
RTECS	WP1925000
F	10
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29335990
Toxicity	LD50 oral in mouse: 1500mg/kg

Product Application of Sulfadiazine CAS#68-35-9

It is an excellent variety of sulfonamide drugs, with strong antibacterial effect, good efficacy, fast absorption, slow excretion, and high effective concentration in the blood. It is clinically used to treat upper respiratory tract infections. Epidemic meningitis, otitis media, furunculosis, puerperal fever, urinary tract infection and acute bacillary dysentery, etc.

Sulfonamide drugs are used to treat infections caused by hemolytic streptococci, pneumococci, meningococci, gonorrhea, and Escherichia coli

Sulfonamide drugs have antibacterial and astringent effects

Sulfonamide antibiotics rely on inhibiting dihydropteroate synthase to prevent the synthesis of dihydropteroate.

Mode of action: Inhibit prokaryotic folic acid synthesis.

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