HARRINGTONINE CAS#26833-85-2

CAS Number: 26833-85-2
Chemical Formula: C28H37NO9
Synonyms:

Natural Harringtonine from Cephalotaxus Fortunei Extract
Anti-leukemia API Intermediate Harringtonine
Cephalotaxine Ester Derivative Raw Powder

Appearance: Off-white to pale yellow crystalline powder, hygroscopic solid

MOQ (Minimum Order Quantity):1g lab trial sample, bulk ≥100g for pharmaceutical R&D factory

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Product Details

HARRINGTONINE CAS#26833-85-2

Harringtonine is a natural alkaloid extracted from branches and leaves of Cephalotaxus fortunei, refined via multi-step solvent extraction, column chromatography and recrystallization purification craft to reach pharmaceutical raw material standard. Strict HPLC content control and impurity inspection follow international pharmacopoeia specification, effectively reducing irrelevant plant extract impurity which would interfere with downstream pharmaceutical formulation development. Its hygroscopic crystalline property requires sealed low-temperature storage to avoid component degradation during long-term warehouse preservation.

Test Item	USP API Grade(Pharmaceutical Bulk)	Lab Research Reagent Grade
Harringtonine Assay(HPLC)	≥98.0%	≥99.0%
Loss on Drying	≤0.50%	≤0.30%
Residual Organic Solvent	Meet ICH Q3C Limit	≤100ppm single solvent
Heavy Metal(Pb/As/Cd)	≤10ppm total	≤5ppm total
Related Substance(Impurity)	≤1.0% single unknown impurity	≤0.50% single impurity

HARRINGTONINE Chemical Properties

Melting point	73～75℃
Boiling point	679.4±55.0 °C(Predicted)
density	1.35±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
pka	11.62±0.29(Predicted)
form	A crystalline solid
color	White to light yellow

Safety Information

RIDADR	1544
HazardClass	6.1(a)
PackingGroup	II

Product Application of HARRINGTONINE CAS#26833-85-2

In pharmaceutical industry, it is core raw intermediate for anti-leukemia and anti-tumor finished drug preparation, widely applied in pre-clinical pharmacology research, new drug formulation screening and generic drug synthesis for global biopharmaceutical enterprises. Besides clinical drug R&D, it is also supplied to university laboratory and pharmaceutical research institute for cell pharmacodynamic experiment and anti-cancer mechanism study. We support small gram-level trial packaging (1g/5g aluminum foil bag) and bulk sealed aluminum can packaging, full set of COA, HPLC spectrum, MSDS and impurity test document can be provided for overseas pharmaceutical institution import registration, customized purification specification is negotiable for long-term R&D cooperation clients.

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