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Chloramphenicol CAS#56-75-7

CAS Number: 56-75-7

Chemical Formula: C11H12Cl2N2O5

Synonyms:

,[theta-(theta,theta)]-C

Acetamide, 2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-

2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,[R-(R*,R*)]-Acetamide

Appearance: White solid

HS Code:29414000

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Chloramphenicol CAS#56-75-7

Chloramphenicol, also known as chloramphenicol, is a broad-spectrum antibiotic produced by Streptomyces chlorinus that has the effect of inhibiting bacterial growth. Natural chloramphenicol is the L-isomer (also known as levomycin). Synthetic products are white or slightly yellow needle-shaped or flaky crystals, odorless, extremely bitter, slightly soluble in water, ether and chloroform, easily soluble in methanol, alcohol, acetone or ethyl acetate, insoluble in benzene and petroleum ether. It is relatively stable in neutral or weakly acidic aqueous solutions and easily loses its effectiveness when exposed to alkali. Synthetic products are racemic, also known as chloramphenicol. Chloramphenicol is a mixture of the L-isomer and the D-isomer of chloramphenicol. Because the D-isomer has no antibacterial effect, the efficacy of chloramphenicol is only half of that of the natural product.

Parameters

Melting point	148-150 °C(lit.)
alpha	19.5 º (c=6, EtOH)
Boiling point	644.9±55.0 °C(Predicted)
density	1.6682 (rough estimate)
refractive index	20 ° (C=5, EtOH)
Fp	14 °C
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	absolute ethanol: soluble5-20mg/mL (as a stock solution)
form	powder
pka	11.03±0.46(Predicted)
color	white
Water Solubility	2.5 g/L (25 º C)
Merck	142077
BRN	2225532
BCS Class	3
InChIKey	WIIZWVCIJKGZOK-RKDXNWHRSA-N
LogP	1.14
CAS DataBase Reference	56-75-7(CAS DataBase Reference)
NIST Chemistry Reference	Chloramphenicol(56-75-7)
IARC	2A (Vol. Sup 7, 50) 1990
EPA Substance Registry System	Chloramphenicol (56-75-7)
Safety Information
Hazard Codes	T,F
Risk Statements	45-11-39/23/24/25-23/24/25
Safety Statements	53-45-16-36/37
RIDADR	2811
WGK Germany	3
RTECS	AB6825000
F	45726
TSCA	Yes
HazardClass	3
HazardClass	IRRITANT
HS Code	29414000
Hazardous Substances Data	56-75-7(Hazardous Substances Data)
Toxicity	LD50 oral in rat: 2500mg/kg

Product Application of Chloramphenicol CAS#56-75-7

It is a broad-spectrum antibacterial antibiotic, the first choice for the treatment of typhoid and paratyphoid, one of the specific drugs for the treatment of anaerobic infections, and secondly for the treatment of various infectious diseases caused by sensitive microorganisms. Due to serious adverse reactions, it is now used less and less. The antibacterial spectrum, effects and uses are the same as chloramphenicol. It is used to treat infections caused by Salmonella typhi, Shigella dysenteriae, Escherichia coli, Salmonella influenzae, Brucella, Pneumococcus, etc., antibiotic anti-infective raw materials

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