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β-Estradiol CAS#50-28-2

CAS Number: 50-28-2

Chemical Formula: C18H24O2C

Synonyms:

BETA-ESTRADIOL-16,16,17-D3

17BETA-ESTRADIOL-16,16,17-D3

β-Estradiol, 99% (dry wt.), ca 3% water

Appearance: White solid

HS Code:29372390

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of β-Estradiol CAS#50-28-2

Estradiol is a steroid hormone that is mainly secreted by ovarian follicles, corpus luteum and placenta during pregnancy. It is the most important and biologically active hormone among estrogens.

Parameters

Melting point	178-179 °C(lit.)
alpha	D25 +76 to +83° (dioxane)
Boiling point	355.44°C (rough estimate)
density	1.0708 (rough estimate)
refractive index	80.4 ° (C=1, Dioxane)
Fp	2℃
storage temp.	room temp
solubility	Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
pka	pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
form	powder
color	White to off-white
biological source	synthetic (organic)
Water Solubility	Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck	143703
BRN	1914275
BCS Class	1
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference	50-28-2(CAS DataBase Reference)
NIST Chemistry Reference	Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System	Estradiol (50-28-2)
Safety Information
Hazard Codes	T,Xn,F
Risk Statements	60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements	53-22-36/37/39-45-36/37-26-16-36-20
RIDADR	2811
WGK Germany	3
RTECS	KG2975000
F	45879
HazardClass	6.1
PackingGroup	III
HS Code	29372390
Hazardous Substances Data	50-28-2(Hazardous Substances Data)
Toxicity	LD50 subcutaneous in rat: > 300mg/kg

Product Application of β-Estradiol CAS#50-28-2

Estradiol can be used as an estrogen drug for functional uterine bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. It can promote and regulate the normal development of female sexual organs and secondary sexual characteristics. It can promote the development and proliferation of breast ducts, but at a large dose, it can inhibit the release of prolactin from the anterior pituitary and reduce milk secretion. It can also be used to stop milk production. However, it may cause nausea, vomiting, and bleeding due to excessive endometrial proliferation. It should be used with caution in patients with liver and kidney dysfunction. It should not be used on the breast, vulva, and vaginal mucosa.

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