Benzbromarone CAS#3562-84-3

CAS Number: 3562-84-3
Chemical Formula: C17H12Br2O3
Synonyms:

LABOTEST-BB LT00134669
BENZBROMARONE
(3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone

Appearance: White Solid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

Contact Now E-Mail Telephone WhatsApp

Product Details

Benzbromarone CAS#3562-84-3

Benzbromarone,a non-competitive inhibitor of xanthine oxidase，is apotent uricosuric drug used in the treatment of gout.
Benzbromarone is a benzofuran derivative chemically related to amiodarone. It increases uric acid excretion by non-specificallyinhibiting its tubular reabsorption.
lt is used in patients with venous disorders to prevent,retard,or reverse varicose degenerative changes in the vessel wall.
Benzbromarone causes diarrhea (3-4% of patients), urate and oxalate stones,urinary sand,renal colic，and allergy in a small number of patients.Liver damage, which reverses after withdrawal, has been described (SEDA-18,108).

Benzbromarone Chemical Properties

Melting point	151°
Boiling point	514.1±50.0 °C(Predicted)
density	1.6211 (rough estimate)
refractive index	1.6010 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent).
pka	4.66±0.25(Predicted)
form	Solid
color	White to Light yellow
Merck	14,1065
Major Application	forensics and toxicology pharmaceutical (small molecule) veterinary
InChI	InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
InChIKey	WHQCHUCQKNIQEC-UHFFFAOYSA-N
SMILES	C(C1=CC(Br)=C(O)C(Br)=C1)(C1C2=CC=CC=C2OC=1CC)=O
CAS DataBase Reference	3562-84-3(CAS DataBase Reference)
EPA Substance Registry System	Methanone, (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)- (3562-84-3)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	OB1804200
TSCA	TSCA listed
HS Code	2932.99.7000
HazardClass	6.1(b)
PackingGroup	III
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral
Toxicity	LD50 oral in rat: 248mg/kg

Product Application Of Benzbromarone CAS#3562-84-3

Benzbromarone is a benzofuran derivative that has been reported to lower serum urate levels in animals and human studies. In normal and hyperuricaemic subjects, benzbromarone reduced serum uric acid levels by one-third to one-half. In comparison with other urate-lowering drugs, 80 mg of micronized or 100 mg of nonmicronized benzbromarone had equal urate-lowering activity to 1–1.5 g of probenecid or 400–800 mg of sulfinpyrazone.
The mechanism of the urate-lowering activity of benzbromarone appears to be attributable to its uricosuric activity. In rats, benzobromarone inhibited urate reabsorption in the proximal tubules when given at 10 mg/kg i.v. In isolated rat liver preparation, benzbromarone inhibits xanthine oxidase in vitro but not in vivo . In humans, this compound only weakly inhibits xanthine oxidase and no increase in urinary excretion of xanthine or hypoxanthine was observed. After oral administration, about 50% of benzbromarone is absorbed. The drug undergoes extensive dehalogenation in the liver and is excreted mainly in the bile and feces. For control of gout the usual therapeutic dose is 100–200 mg daily. Benzbromarone has few side effects and is usually well tolerated.

Fact Factory and Equipment Show

Gardenia Yellow#94238-00-3