Trifluoromethanesulfonic anhydride CAS#358-23-6

CAS Number: 358-23-6
Chemical Formula: C2F6O5S2
Synonyms:

Methanesulfonic acid, trifluoro-, anhydride
Trifluoromethanesulfonic anhydride solution
TRIFLUOROMETHANE SULFONIC ANHYDRIDE(ORIG INAL IMPORT VIDE BE.NO

Appearance: Transperant liquid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Trifluoromethanesulfonic anhydride CAS#358-23-6

Trifluoromethanesulfonic anhydride, also known as triflic anhydride, has proven to be an extraordinary reagent for a broad range of transformations. As a commercially and readily available reagent, It has been widely used in synthetic chemistry due to its high electrophilicity. Given its high affinity towards O-nucleophiles, reaction with alcohols, carbonyls, sulfur phosphorus- and iodine oxides towards the formation of the corresponding triflates is strongly favored. As one of the premier leaving groups in organic chemistry, the generated triflates then open the door to various downstream transformations, including (but not limited to) substitution reactions, cross-coupling processes, redox reactions, and rearrangements[1-2].

Trifluoromethanesulfonic anhydride Chemical Properties

Melting point	-80°C
Boiling point	81-83 °C (lit.)
density	1.677 g/mL at 25 °C (lit.)
vapor density	5.2 (vs air)
vapor pressure	8 mm Hg ( 20 °C)
refractive index	n20/D 1.321(lit.)
RTECS	PB2772000
Fp	81-83°C
storage temp.	Store below +30°C.
solubility	Miscible with dichloromethane. Immiscible with hydrocarbons.
form	Liquid
color	Clear colorless to light brown
Specific Gravity	1.677
Water Solubility	reacts violently with water
Sensitive	Moisture Sensitive
BRN	1813600
Stability:	Hygroscopic, Moisture Sensitive
InChIKey	WJKHJLXJJJATHN-UHFFFAOYSA-N
LogP	0.3 at 25℃
CAS DataBase Reference	358-23-6(CAS DataBase Reference)
NIST Chemistry Reference	Trifluoromethanesulfonic anhydride(358-23-6)
EPA Substance Registry System	Methanesulfonic acid, trifluoro-, anhydride (358-23-6)

Safety Information

Hazard Codes	C
Risk Statements	14-21/22-34-35-22-40
Safety Statements	26-36/37/39-43-45-8
RIDADR	UN 3265 8/PG 2
WGK Germany	3
F	10-21
Hazard Note	Corrosive
TSCA	Yes
HazardClass	8
PackingGroup	I
HS Code	29049020
Toxicity	LD50 orally in Rabbit: 1012 mg/kg

Product Application of Trifluoromethanesulfonic anhydride CAS#358-23-6

Trifluoromethanesulfonic anhydride is used to convert phenols and imine into triflic ester and NTf group. It is a strong electrophile used for the introduction of triflyl group in chemical synthesis. It serves as a reagent in the preparation of alkyl and vinyl triflates, and for the stereoselective synthesis of mannosazide methyl uronate donors. It acts as a catalyst for glycosylation with anomeric hydroxy sugars to prepare polysaccharides.

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