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DBU CAS# 6674-22-2

CAS Number:6674-22-2
Chemical Formula: C9H16N2
Synonyms:

1,8-Diazabicyclo(5 x 4 x 0)undec-7-ene

1,8-Diazabicyclo[5.4.0]undecane-7-ene
1,8-DIAZEBICYCLO[5.4.0]UNDEC-7-ENE

Appearance: Yellow liquid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

DBU CAS# 6674-22-2

DBU is a bicyclic amidine base. It is non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry. It is reported to be superior to amine catalyst in Baylis-Hillman reaction.It promotes the methylation reaction of phenols, indoles and benzimidazoles with dimethyl carbonate under mild conditions.We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.

DBU Chemical Properties

Melting point	-70 °C
Boiling point	80-83 °C0.6 mm Hg(lit.)
density	1.019 g/mL at 20 °C(lit.)
vapor pressure	5.3 mm Hg ( 37.7 °C)
refractive index	n20/D 1.523
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	soluble
form	Liquid
pka	13.28±0.20(Predicted)
color	Clear colorless to light yellow
Odor	Unpleasant
PH	12.8 (10g/l, H2O, 20℃)
PH Range	12.8 at 10 g/l at 20 °C
explosive limit	1.1-6.5%(V)
Water Solubility	soluble
Sensitive	Air Sensitive
BRN	508906
Stability:	Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.
InChIKey	GQHTUMJGOHRCHB-UHFFFAOYSA-N
CAS DataBase Reference	6674-22-2(CAS DataBase Reference)
NIST Chemistry Reference	1,8-diazabicyclo [5.4.0]undec-7-ene(6674-22-2)
EPA Substance Registry System	Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro- (6674-22-2)

Safety Information

Hazard Codes	C,F
Risk Statements	22-34-52/53-35-40-37-19-11-67
Safety Statements	26-36/37/39-45-61-27-16
RIDADR	UN 3267 8/PG 2
WGK Germany	2
F	34
Autoignition Temperature	260 °C
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29339930
Toxicity	LD50 orally in Rabbit: 215 - 681 mg/kg

Product Application of DBU CAS# 6674-22-2

DBU may be used:

as catalyst for carboxylic acid esterification with dimethyl carbonate

in the synthesis of duocarmycin and CC-1065 analogs

as catalyst in aza-Michael addition and Knovenegal condensation reaction

as base for dehalogenation of halogenated Diels-Alder adducts and the resulting activated 2,4-dienones were subjected to regio- and stereo-directed Michael additions, using Yamamoto′s reagent (CH3Cu · BF3)

in a new synthesis of the ABCD ring system of Camptothecin

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