Panthenol CAS#16485-10-2

CAS Number: 16485-10-2
Chemical Formula: C9H19NO4
Synonyms:

2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(+-)-Butanamide
4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(+/-)-butanamid
DL-PANTHENOL

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Panthenol CAS#16485-10-2

Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.
Panthenol is a multi-functional active ingredient that would be useful in most skin care formulations. Its efficacy has been substantiated in numerous peer-reviewed journals. The biologically active form of Panthenol, D-panthenol (EU), is the stable alcohol analogue of vitamin B5, pantothenic acid (EU), and is quickly converted to vitamin B5 (pantothenate) in the body. Pantothenic acid is present in all living cells and acts as an essential nutritional component due to its role in the formation of acetyl-co-enzyme A in the early stages of metabolism. The main role of acetyl-co-enzyme A is to provide activated acetic acid into the citric acid cycle (Krebs Cycle). This produces carbon dioxide, water, and energy. Co-enzyme A also transfers to other molecules such as Nacetyl-glucosamine (EU) and acetylcholine (EU) to help in the production of steroids and the synthesis of fatty acids. Coenzyme A also helps the body detoxify foreign substances.

Panthenol Chemical Properties

Melting point	66-69 °C (lit.)
alpha	0°(c=5, H2O)
Boiling point	118-120 °C(Press: 0.02 Torr)
density	1.166±0.06 g/cm3(Predicted)
vapor pressure	0.004Pa at 25℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	13.03±0.20(Predicted)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water, ethanol, ether, chloroform, and propylene glycol.
Sensitive	Hygroscopic
Merck	14,2947
BRN	1724945
Cosmetics Ingredients Functions	HAIR CONDITIONING ANTISTATIC SKIN CONDITIONING
Cosmetic Ingredient Review (CIR)	Panthenol (16485-10-2)
InChI	1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)
InChIKey	SNPLKNRPJHDVJA-UHFFFAOYSA-N
SMILES	CC(C)(CO)C(O)C(=O)NCCCO
LogP	-1.02 at 22℃
CAS DataBase Reference	16485-10-2(CAS DataBase Reference)
EPA Substance Registry System	Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl- (16485-10-2)

Safety Information

Hazard Codes	Xn
Risk Statements	36/37/38-48-41-37/38-20/21/22
Safety Statements	26-37-45-36/37/39-22
WGK Germany	3
RTECS	ES4316500
F	3
TSCA	TSCA listed
HS Code	29362400
Storage Class	11 - Combustible Solids
Toxicity	mouse,LD50,intraperitoneal,10100mg/kg (10100mg/kg),Farmaco, Edizione Scientifica. Vol. 14, Pg. 43, 1959.

Product Application Of Panthenol CAS#16485-10-2

Panthenol is used as a moisturizer, soothing and softening agent.

Skin care: It improves hydration and elasticity of the skin, reduces itching and inflammation of the skin, improves skin elasticity, and accelerates the rate of healing of wounds. In topical creams, it is found to be in a concentration of 1-5%.
Hair care: It binds to the hair shaft readily, so, it is a common component of commercial shampoos and hair conditioners (in concentrations of 0.1-1%). It coats the hair and seals its surface, lubricating the hair shaft and giving it a shiny appearance. It can also help protect your hair from styling or environmental damage by locking in moisture.

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