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Methyl Paraben CAS#99-76-3
CAS Number: 99-76-3
Chemical Formula: C8H8O3
Synonyms:
NIPAGIN PLAIN
P-HYDROXYBENZOIC ACID METHYL ESTER
Appearance: White Solid
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Methyl Paraben CAS#99-76-3
Methylparaben is a colorless crystalline powder with a faint characteristic odor and a slight burning taste. It is slightly soluble in water but easily dissolves in ethanol, ether, acetone, and other organic solvents. One gram can dissolve in 2.5 ml of ethanol, approximately 4 ml of propylene glycol, or 400 ml of water at 25°C or about 50 ml of water at 80°C. It is commonly used as a fungistat in soft drinks, non-leavened bakery products, and other products, with a permissible level of up to 0.1%. To inhibit Gram-positive bacteria, 1000 to 4000 ppm are required, and its effectiveness increases with decreasing pH, similar to benzoates.
Methylparaben Chemical Properties |
Melting point | 125-128 °C (lit.) |
Boiling point | 298.6 °C |
density | 1,46g/cm |
vapor pressure | 0.000005 hPa (20 °C) |
refractive index | 1.4447 (estimate) |
FEMA | 2710 | METHYL P-HYDROXYBENZOATE |
Fp | 280°C |
storage temp. | room temp |
solubility | ethanol: soluble0.1M, clear, colorless |
pka | pKa 8.15(H2O,t =20.0) (Uncertain) |
form | Crystalline Powder |
color | White to almost white |
Odor | odorless or faint char. odor, sl. burning taste |
PH | 5.8 (H2O, 20°C) (saturated solution) |
biological source | synthetic |
Water Solubility | Slightly soluble in water. |
FreezingPoint | 131℃ |
Merck | 14,6107 |
BRN | 509801 |
Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
Major Application | flavors and fragrances |
Cosmetics Ingredients Functions | PRESERVATIVE |
Cosmetic Ingredient Review (CIR) | Methylparaben (99-76-3) |
InChI | 1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3 |
InChIKey | LXCFILQKKLGQFO-UHFFFAOYSA-N |
SMILES | COC(=O)c1ccc(O)cc1 |
LogP | 1.98 at 20℃ |
CAS DataBase Reference | 99-76-3(CAS DataBase Reference) |
NIST Chemistry Reference | Benzoic acid, 4-hydroxy-, methyl ester(99-76-3) |
EPA Substance Registry System | Methylparaben (99-76-3) |
Safety Information |
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-20/21/22-36 |
Safety Statements | 26-36-24/25-39 |
RIDADR | UN 2769 |
WGK Germany | 1 |
RTECS | DH2450000 |
Autoignition Temperature | >600 °C |
TSCA | TSCA listed |
HS Code | 29182930 |
Storage Class | 11 - Combustible Solids |
Hazard Classifications | Aquatic Chronic 2 |
Hazardous Substances Data | 99-76-3(Hazardous Substances Data) |
Toxicity | LD50 orally in Rabbit: 2100 mg/kg |
Product Application of Methyl Paraben CAS#99-76-3
Methylparaben is the ester of methyl alcohol and p-hydroxybenzoic acid, It is a bacteriostatic agent and preservative that was added to local anesthetic agents without vasoconstrictors before 1984 to prevent bacterial growth. Allergic reactions developed from repeated exposures to parabens led to the removal of this agent from dental anesthetic solutions. Similar products produced by similar production methods, like ethyl p-hydroxybenzoate (paraben B) and propyl p-hydroxybenzoate (Nepalese c), are also disinfectant preservatives. The products are irritating to the skin.
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