Glycidol CAS#556-52-5

CAS Number: 556-52-5
Chemical Formula: C3H6O2
Synonyms:

GLYCEROLGLYCIDE
GLYCIDOL
2,3-EPOXYPROPAN-1-OL

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Glycidol CAS#556-52-5

Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.

Glycidol Chemical Properties

Melting point	-54 °C
Boiling point	61-62 °C/15 mmHg (lit.)
density	1.117 g/mL at 25 °C (lit.)
vapor density	2.15 (vs air)
vapor pressure	0.9 mm Hg ( 25 °C)
refractive index	n20/D 1.433(lit.)
Fp	178 °F
storage temp.	-20°C
solubility	Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986)
form	Powder, Crystals or Chunks
pka	14.62±0.10(Predicted)
color	White to light yellow-beige
Water Solubility	soluble
Merck	13,4503
BRN	383562
Exposure limits	TLV-TWA 75 mg/m3 (25 ppm) (ACGIH); 150 mg/m3 (50 ppm) (OSHA); IDLH 500 ppm (NIOSH).
Stability:	Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air.
InChI	1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2
InChIKey	CTKINSOISVBQLD-UHFFFAOYSA-N
SMILES	OCC1CO1
LogP	-0.95 at 25℃
CAS DataBase Reference	556-52-5(CAS DataBase Reference)
IARC	2A (Vol. 77) 2000
NIST Chemistry Reference	Glycidol(556-52-5)
EPA Substance Registry System	Glycidol (556-52-5)

Safety Information

Hazard Codes	T
Risk Statements	45-60-21/22-23-36/37/38-68
Safety Statements	53-45-36/37-26
OEB	A
OEL	TWA: 25 ppm (75 mg/m3)
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	UB4375000
F	10-21
Autoignition Temperature	780 °F
Hazard Note	Toxic
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
HS Code	29109000
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 2 Inhalation Acute Tox. 4 Dermal Acute Tox. 4 Oral Carc. 1B Eye Irrit. 2 Muta. 2 Repr. 1B Skin Irrit. 2 STOT SE 3
Hazardous Substances Data	556-52-5(Hazardous Substances Data)
Toxicity	Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985).
IDLA	150 ppm

Product Application Of Glycidol CAS#556-52-5

Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.

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