Betulin CAS#473-98-3

CAS Number: 473-98-3
Chemical Formula: C30H50O2
Synonyms:

BETULIN(P)
BETULIN hplc
Betulinic alcohol

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Betulin CAS#473-98-3

Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active form and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. Betulin, the precursor of betulinic acid, is a pentacyclic triterpene found in the bark of birch trees. Betulin inhibits the SREBP-driven pathway of cholesterol and fatty acid biosynthesis by promoting SCAP–Insig binding which prevents the activation and release of SREBP-2 from the ER. At 15-30 mg/kg/day, betulin has been shown to decrease lipid levels and increase insulin sensitivity in mice fed a western-type diet. In an atherosclerosis disease model, 30 mg/kg/day betulin can reduce the size and improve the stability of atherosclerotic plaques in LDLR-knockout mice. At 2.5-5 μg/ml betulin, in combination with cholesterol, demonstrates anticancer effects by inducing apoptosis in Jurkat cells, A549 lung carcinoma cells, and HeLa cervical carcinoma cells.

Betulin Chemical Properties

Melting point	256-257 °C(lit.)
alpha	D15 +20° (c = 2 in pyridine)
Boiling point	493.26°C (rough estimate)
density	0.9882 (rough estimate)
refractive index	1.5045 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly, Heated)
form	Off-white powder
pka	15.10±0.10(Predicted)
color	Pale Brown to Beige
Optical Rotation	+2015 (c 6, pyridine)
Merck	14,1189
Stability:	Hygroscopic
Major Application	food and beverages
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChIKey	FVWJYYTZTCVBKE-ROUWMTJPSA-N
SMILES	[H][C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O)C(C)(C)[C@]4([H])CC[C@@]3(C)[C@]1(C)CC[C@@]5(CO)CC[C@@H](C(C)=C)[C@]25[H]
LogP	8.607 (est)
CAS DataBase Reference	473-98-3(CAS DataBase Reference)
NIST Chemistry Reference	Betulin(473-98-3)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	36/37/38-20/21/22-68/20/21/22-68
Safety Statements	36/37-36-26
WGK Germany	3
RTECS	OK5755000
HS Code	29181985
Storage Class	11 - Combustible Solids
Hazard Classifications	STOT SE 2

Product Application of Betulin CAS#473-98-3

birch bark extract is described as having anti-irritant and antiseptic properties, and effective in acne treatment. It is used to make sunburn products, soothing lotions, and aftershaves. The oil is astringent and is mainly used for its curative effects, especially in cases of acne and eczema. In folkloric medicine, birch bark extract was considered good for bathing skin eruptions. Destructive distillation of the bark’s white epidermis yields an empyreumatic oil known as oil of birch tar, Oleum rusci, or dagget. This is a thick, bituminous, brownish-black liquid with a pungent, balsamic odor. It contains a high percentage of methylsalicilate, creosol, and guaiacol and is almost identical to wintergreen oil.

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