4-Dimethylaminopyridine CAS#1122-58-3

CAS Number: 1122-58-3
Chemical Formula: C7H10N2
Synonyms:

4-(Dimethylamino)PyridineForSynthesis
AKOS BBS-00004314
AURORA KA-6495

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

4-Dimethylaminopyridine CAS#1122-58-3

DMAP (m.p. 112-113°C,1122-58-3) and PPY (m.p. 57-58°C)[4] are colorless, crystalline substances which are very soluble in methanol, ethyl acetate, chloroform, methylene chloride, 1,2-dichloroethane, acetone, and acetic acid and less soluble in cold hexane, cyclohexane, and water. DMAP can be recrystallized from ethyl acetate and PPY from pentane or hexane. The basicities of DMAP[5] and PPY in water as well as the dipole moment of DMAP[7-9] in benzene and dioxane have been determined by several groups. Of especial interest are the thermodynamic investigations concerned with the protonation of DMAP in water[11] and calculations whereby the influence of substituents on the basicity has been determined[6, 9, 10].

4-Dimethylaminopyridine Chemical Properties

Melting point	112 °C
Boiling point	162 °C
bulk density	520kg/m3
density	0.906 g/mL at 25 °C
vapor pressure	0.169 hPa at 20 °C
refractive index	n20/D 1.431
Fp	110 °C
storage temp.	Store below +30°C.
solubility	methanol: 50 mg/mL, clear
pka	pKa (20°): 9.7
form	prilled
color	off-white to yellow
Odor	characteristic odor
PH	11 (60g/l, H2O, 20℃)
PH Range	9.7 (10% aq soln)
Water Solubility	76 g/L (25 ºC)
Merck	14,3389
BRN	110354
Stability:	Stable. Incompatible with acids, oxidizing agents.
InChI	1S/C7H10N2/c1-9(2)7-3-5-8-6-4-7/h3-6H,1-2H3
InChIKey	VHYFNPMBLIVWCW-UHFFFAOYSA-N
SMILES	CN(C)c1ccncc1
LogP	1.34 at 25℃
CAS DataBase Reference	1122-58-3(CAS DataBase Reference)
NIST Chemistry Reference	4-Pyridinamine, N,N-dimethyl-(1122-58-3)
EPA Substance Registry System	4-(Dimethylamino)pyridine (1122-58-3)

Safety Information

Hazard Codes	T,C,T+,Xn,F
Risk Statements	25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19
Safety Statements	36/37/39-45-28A-26-28-36/37-53-27-22-16
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS	US8400000
Autoignition Temperature	420 °C
Hazard Note	Toxic/Corrosive
TSCA	TSCA listed
HazardClass	8
PackingGroup	II
HS Code	29333999
Storage Class	6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications	Acute Tox. 2 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Chronic 2 Eye Dam. 1 Skin Irrit. 2 STOT SE 1
Toxicity	LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg

Product Application of 4-Dimethylaminopyridine CAS#1122-58-3

4-Dimethylaminopyridine is a versatile hypernucleophilic acylation catalyst, it is used to improve the yield, reduce the reaction time, improving relaxation process conditions. Widely used in perfumes, dyes, pigments, pesticides, pharmaceuticals and polymer compounds and other fields. Also used as a catalyst for the synthesis of polyurethane, a curing agent and a blowing catalyst.

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