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4,4'-Diaminodiphenylsulfone CAS#80-08-0
CAS Number: 80-08-0
Chemical Formula: C12H12N2O2S
Synonyms:
DISULONE
FREE SAMPLE NCV 4,4-DIAMINO DIPHENYL SULPHONE STD
BIS(P-AMINOPHENYL)SULFONE
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Appearance: White Powder
4,4'-Diaminodiphenylsulfone CAS#80-08-0
A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacteriu leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
4,4'-Diaminodiphenylsulfone Chemical Properties |
Melting point | 175-177 °C(lit.) |
Boiling point | 511.7±35.0 °C(Predicted) |
bulk density | 250-350kg/m3 |
density | 1.2701 (rough estimate) |
vapor pressure | 0.004Pa at 25℃ |
refractive index | 1.5950 (estimate) |
storage temp. | 2-8°C |
solubility | 0.38g/l |
pka | pKb 13.0(at 25℃) |
form | Crystalline Powder |
color | White to beige |
PH | 5.5-7.5 (H2O, 20℃)(saturated aqueous solution) |
Water Solubility | <0.1 g/100 mL at 20 ºC |
Merck | 14,2822 |
BRN | 788055 |
BCS Class | 4,2 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
InChI | 1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2 |
InChIKey | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
SMILES | Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 |
LogP | 0.97 at 25℃ |
CAS DataBase Reference | 80-08-0(CAS DataBase Reference) |
IARC | 3 (Vol. 24, Sup 7) 1987 |
NIST Chemistry Reference | Dapsone(80-08-0) |
EPA Substance Registry System | Dapsone (80-08-0) |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 22 |
RIDADR | 3249 |
WGK Germany | 1 |
RTECS | BY8925000 |
TSCA | TSCA listed |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 29051620 |
HS Code | 29309070 |
Storage Class | 6.1C - Combustible acute toxic Cat.3 |
Hazard Classifications | Acute Tox. 4 Oral |
Hazardous Substances Data | 80-08-0(Hazardous Substances Data) |
Toxicity | LD50 orally in Rabbit: 1000 mg/kg LD50 dermal Rabbit > 4000 mg/kg |
Product Application of 4,4'-Diaminodiphenylsulfone CAS#80-08-0
Dapsone is approved for the treatment of an autoimmune blistering skin disease, dermatitis herpetiformis. This intensely pruritic eruption is characterized histologically by a dense dermal infiltration of neutrophils and subepidermal blisters. Other skin diseases in which dapsone is helpful are linear immunoglobulin A (IgA) dermatosis, subcorneal pustular dermatosis, leukocytoclastic vasculitis, and a variety of rarer eruptions in which neutrophils predominate, including some forms of cutaneous lupus erythematosus.
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