Dimethyl fumarate CAS#624-49-7

CAS Number: 624-49-7
Chemical Formula: C6H8O4
Synonyms:

But-2-enedioicaciddimethylester
Fumaric acid, bis-methyl ester
Dimethyl fumaratedisc. 10/26/00

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.

Dimethyl fumarate Chemical Properties

Melting point	102-106 °C (lit.)
Boiling point	192-193 °C (lit.)
density	1,37 g/cm3
vapor pressure	5 hPa (25 °C)
refractive index	1.4062 (estimate)
Fp	192-193°C
storage temp.	Store below +30°C.
solubility	1.6g/l
form	Liquid
color	Clear colorless to faintly yellow
PH	4.0-6.0 (10g/l, H2O, 20℃)suspension
Water Solubility	Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
Merck	14,4287
BRN	774590
Stability:	Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
InChI	1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
InChIKey	LDCRTTXIJACKKU-ONEGZZNKSA-N
SMILES	[H]\C(=C(\[H])C(=O)OC)C(=O)OC
CAS DataBase Reference	624-49-7(CAS DataBase Reference)
NIST Chemistry Reference	2-Butenedioic acid (E)-, dimethyl ester(624-49-7)
EPA Substance Registry System	2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7)

Safety Information

Hazard Codes	Xn
Risk Statements	21-38-41-43-36/37/38-36/38
Safety Statements	26-36/37/39-36/37
RIDADR	UN 3077 9 / PGIII
WGK Germany	1
RTECS	EM6125000
TSCA	TSCA listed
HazardClass	9
HS Code	29171990
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Aquatic Chronic 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3
Hazardous Substances Data	624-49-7(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg

PRoduct Application Of Dimethyl fumarate CAS#624-49-7

Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing

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