LACTITOL CAS#585-86-4

CAS Number: 585-86-4
Chemical Formula: C12H24O11
Synonyms:

4-β-D-galactopyranosyl-D-glucito1
4-O-B-D-GALACTOPYRANOSYL-D-GLUCITOL MONOHYDRATE
Lactnol

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

LACTITOL CAS#585-86-4

Lactitol (4-o-(|3-D-Galactopyranosyl)-D-glucitol) is a disaccharide sugar alcohol derived from lactose by reduction of its glucose moiety. Lactitol has not been found in nature. It is about 0.4 times as sweet as sucrose.
In vitro studies with galactosidase-containing enzyme preparations have demonstrated that lactitol is hydrolyzed only very slowly. In incubations with human intestinal biopsies, it has been shown that the human intestinal mucosa does not exhibit any significant dis accharidase activity with lactitol as a substrate. The hydrolytic activities towards lactitol and isomalt were only 1.3% of those towards lactose and isomaltulose, respectively. Corresponding exper iments with intestinal preparations of germ-free pigs and convention ally kept minipigs gave similar results. These observations indicate that lactitol is the most slowly digested disaccharide sugar alcohol. However, in vitro investigations with intestinal enzyme prepara tions provide only relative figures on hydrolysis rates. Experiments with humans and 14C-labeled lactitol during jejunal perfusion indi cate that lactitol is virtually not assimilated by the human small intestine. After passage through the small intestine, ingested lac titol reaches the bacterially colonized segments of the gut where intensive fermentation takes place. Short-chain fatty acids (acetate, propionate, butyrate) are the major fermentation end products which are subsequently further metabolized by the host.

LACTITOL Chemical Properties

Melting point	146°
alpha	D23 +14° (c = 4 in water)
Boiling point	788.5±60.0 °C(Predicted)
density	1.69±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
solubility	Slightly soluble in ethanol (95%) and ether. Soluble 1 in 1.75 of water at 20°C; 1 in 1.61 at 30°C; 1 in 1.49 at 40°C; 1 in 1.39 at 50°C.
pka	12.84±0.70(Predicted)
form	Solid
color	White to Off-White
Odor	odorless
Optical Rotation	[α]/D 14.5±1.5°, c =1 in H2O
Cosmetics Ingredients Functions	SKIN CONDITIONING HUMECTANT
InChI	InChI=1/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-/s3
InChIKey	VQHSOMBJVWLPSR-PHBIKYJVNA-N
SMILES	[C@@H]1([C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)CO \|&1:0,1,3,4,6,12,13,17,19,r\|
LogP	-3.11

Safety Information

Hazardous Substances Data

585-86-4(Hazardous Substances Data)

Product Application of LACTITOL CAS#585-86-4

Lactitol is used as a noncariogenic replacement for sucrose. It is also used as a diluent in solid dosage forms.(1) A direct-compression form is available,(2,3) as is a direct-compression blend of lactose and lactitol. Lactitol is also used therapeutically in the treatment of hepatic encephalopathy and as a laxative.

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