Curcumin CAS#458-37-7

Products Description of Curcumin CAS#458-37-7

Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; ) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.

Parameters

Melting point	183 °C
Boiling point	418.73°C (rough estimate)
density	0.93
vapor density	13 (vs air)
refractive index	1.4155-1.4175
Fp	208.9±23.6 °C
storage temp.	2-8°C
solubility	ethanol: 10 mg/mL
pka	8.09(at 25℃)
form	powder
Colour Index	75300
color	orange
Odor	Odorless
PH Range	Yellow (7.8) to red-brown (9.2)
biological source	Curcuma longa (Turmeric)
Water Solubility	Slightly soluble (hot)
λmax	430nm
Merck	14,2673
BRN	2306965
Concentration	1 mCi/ml
Solvent	Ethanol
Specific Activity	5-15 Ci/mmol
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major Application	Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKey	VFLDPWHFBUODDF-FCXRPNKRSA-N
LogP	3.290 (est)
CAS DataBase Reference	458-37-7(CAS DataBase Reference)
EPA Substance Registry System	Curcumin (458-37-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
RTECS	MI5230000
Hazard Note	Irritant
TSCA	Yes
HS Code	29145000
Hazardous Substances Data	458-37-7(Hazardous Substances Data)
Toxicity	LD50 Oral-Rat-12.200 mg/kg

Product Application of  Curcumin CAS#458-37-7

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

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Fast delivery time

Inventory 2-3 working days New production 7-10 working days