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Ibuprofen CAS#15687-27-1

CAS Number: 15687-27-1

Chemical Formula: C13H18O2

Synonyms:

(+/-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID

2-(4-ISOBUTYLPHENYL)PROPIONIC ACID

4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID

Appearance: White crystalline powder

HS Code:29163920

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Ibuprofen CAS#15687-27-1

Ibuprofen, also known as ibuprofen, is a non-steroidal anti-inflammatory analgesic. It has good anti-inflammatory, analgesic and antipyretic effects with few adverse reactions. It has been widely used in the world and has become one of the world's best-selling over-the-counter drugs. It is listed as one of the three pillar products of antipyretic and analgesic drugs together with aspirin and paracetamol. In my country, it is mainly used for pain relief and anti-rheumatic effects, but not much for colds and fever reduction, which is far less than paracetamol and aspirin.

Parameters

Melting point	77-78 °C
Boiling point	157 °C (4 mmHg)
alpha	[α]D20 -1～+1°(c=1,C2H5OH)
density	1.0364 (rough estimate)
refractive index	1.5500 (estimate)
Fp	9℃
storage temp.	2-8°C
solubility	Practically insoluble in water, freely soluble in acetone, in methanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides and carbonates.
pka	pKa 4.45± 0.04(H2O,t = 25±0.5,I=0.15(KCl))(Approximate)
form	Crystalline Powder
color	white to off-white
biological source	synthetic (organic)
Water Solubility	insoluble
Merck	144881
BCS Class	2
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey	HEFNNWSXXWATRW-UHFFFAOYSA-N
LogP	3.97
CAS DataBase Reference	15687-27-1(CAS DataBase Reference)
NIST Chemistry Reference	Ibuprofen(15687-27-1)
EPA Substance Registry System	Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)- (15687-27-1)
Safety Information
Hazard Codes	Xn
Risk Statements	22-63-51/53-39/23/24/25-23/24/25-11
Safety Statements	36-61-36/37-45-16-7
HS Code	29163920
Hazardous Substances Data	15687-27-1(Hazardous Substances Data)
Toxicity	LD50 in male mice, rats (mg/kg): 495, 626 i.p.; 1255, 1050 orally (Orzalesi)

Product Application of Ibuprofen CAS#15687-27-1

It has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in treating rheumatism and rheumatoid arthritis. It is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis. This product ranked 13th in the sales ranking of US drugs in 1985.

It is used as a PG synthase inhibitor with antipyretic, analgesic and anti-inflammatory effects

It is a COX inhibitor with greater inhibitory activity on COX-1 than on COX-2.

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