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Artemisinin CAS#63968-64-9

CAS Number: 63968-64-9

Chemical Formula: C15H22O5

Synonyms:

QHS;ARTEMISININ 99%

qinghausu

Appearance: White crystal

HS Code:29322985

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Products Description of Artemisinin CAS#63968-64-9

Artemisinin is the most effective drug for treating malaria. It is a sesquiterpene lactone drug with peroxide groups extracted from the traditional Chinese medicine Artemisia annua. It has the characteristics of high efficiency, rapid effect, heat-clearing and summer-heat-relieving, heat-removing, protozoon-killing, and low toxicity. At present, the efficacy of artemisinin-based combined therapy (ACT) for the treatment of malaria has reached more than 90% in all parts of the world. It has been widely used in the treatment of malaria in countries around the world. It has a strong and rapid killing effect on the erythrocytic stage of Plasmodium, and can quickly control clinical attacks and symptoms. At the same time, it has outstanding effects on chicken coccidiosis, swine eperythrozoonosis, toxoplasmosis, yin deficiency fever, damp-heat jaundice, vivax malaria, malignant malaria, cerebral malaria and chloroquine-resistant malaria.

Parameters

Melting point	156-157 °C (lit.)
alpha	76 º (c=0.5,MeOH)
Boiling point	344.94°C (rough estimate)
density	1.0984 (rough estimate)
refractive index	75 ° (C=0.5, MeOH)
storage temp.	-20°C
solubility	Soluble to 100mM in DMSO and to 75mM in ethanol
form	White to off-white crystalline solid.
color	Needles
optical activity	[α]20/D +76°, c = 0.5 in methanol
Merck	14817
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.
InChI	InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
InChIKey	BLUAFEHZUWYNDE-NNWCWBAJSA-N
SMILES	O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1
LogP	2.9
Safety Information
Safety Statements	22-24/25
WGK Germany	2
RTECS	KD4170000
HS Code	29322985
Toxicity	LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu)

Product Application of Artemisinin CAS#63968-64-9

Artemisia annua is used as an antimalarial drug. Clinical applications have shown that artemisinin and its derivatives are effective against Plasmodium malaria and malignant malaria, especially Artemtherin, which has a stronger effect on killing asexual bodies in Plasmodium cells than other artemisinin drugs. It has the advantages of high efficiency, rapid effect, low toxicity and no cross-resistance with chloroquine. It can be used not only for treatment but also for emergency treatment. It is suitable for various malaria, such as malignant malaria, vivax malaria, chloroquine-resistant malaria and cerebral malaria. Including dangerous types. The most eye-catching is dihydroartemisinin and its tablets. The antimalarial efficacy of this drug is 10 times higher than that of artemisinin, and the recurrence rate is only 1.95%. Therefore, it was rated as one of the top ten scientific and technological achievements in China's Chemicalbook in 1992. Artemisinin and its derivatives are not only an excellent antimalarial drug, but also have potential attractive prospects in the treatment of other diseases. Animal experiments have found that the deworming rate of artemisinin in treating mouse Clonorchis sinensis can reach 100%; the deworming rate of treating animal schistosomiasis is 33.8-99.3%. The total effective rate of artemisinin in treating discoid lupus erythematosus is 90%. The efficacy of artemisinin in treating dengue fever is significantly better than that of western medicines such as morphine. Immunologists have also found in their research that artemisinin can significantly increase the transformation rate of lymphocytes and enhance the immune function of antibodies. No toxic effects on the heart, liver, or kidneys have been found. There are no obvious side effects in clinical practice.

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