5-Bromo-2-chloropyrimidine CAS#32779-36-5

CAS Number:32779-36-5
Chemical Formula: C4H2BrClN2
Synonyms:

Macitentan Impurity 27
Macitentan Intermediate 5
5-BROMO-2-CHLOROPYRIMIDINE

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

Contact Now E-Mail Telephone WhatsApp

Product Details

5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is a halogenated pyrimidine analogue containing chloro and bromo substituents at positions 2 and 5 of the benzene ring structure. The compound is used as a pharmaceutical intermediate in the preparation of macitentan, an endothelin receptor antagonist drug for the treatment of pulmonary hypertension.

5-Bromo-2-chloropyrimidine Chemical Properties

Melting point	73-79 °C (lit.)
Boiling point	95°C 15mm
density	1.859±0.06 g/cm3(Predicted)
Fp	95°C/15mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-2.84±0.22(Predicted)
form	Crystalline Powder
color	Off-white to beige
Water Solubility	insoluble
BRN	507955
Stability:	Hygroscopic
InChI	InChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H
InChIKey	XPGIBDJXEVAVTO-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(Br)C=N1
CAS DataBase Reference	32779-36-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/39-37/39-36
RIDADR	UN 3335
WGK Germany	3
HazardClass	IRRITANT
HS Code	29335990

Product Application of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is applied as a pharmaceutical intermediate, in the synthesis of pharmaceutical goods such as inhibitors. It is also employed in the cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines.

Factory and Equipment Show

Gardenia Yellow#94238-00-3