Terbinafine CAS#91161-71-6

CAS Number: 91161-71-6
Chemical Formula: C21H25N
Synonyms:

trans-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthylmethylamine
LAMISIL
(E)-N-(6，6-I)imethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Terbinafine CAS#91161-71-6

Terbinafine (Lamisil) is a second-generation allylamine that is related to naftifine; however, it is 10 to 100 times more potent in vitro. It is fungicidal, whereas griseofulvin, ketoconazole, itraconazole, and other azole derivatives are all fungistatic. Because it is fungicidal, duration of therapy is shorter, and relapse rates are less than with other oral or topical therapies. Terbinafine acts by inhibiting squalene epoxidase and thereby decreasing synthesis of ergosterol, an essential component of fungal cell membranes. It is highly lipophilic and concentrates in the stratum corneum, sebum, and hair follicles. Slightly better cure rates are attained with b.i.d. than with daily dosing.

Terbinafine Chemical Properties

Melting point	203-205 °C
Boiling point	417.9±33.0 °C(Predicted)
density	1.007±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
storage temp.	2-8°C
solubility	soluble in Methanol
pka	6.92±0.50(Predicted)
form	powder to crystal
color	White to Light yellow
LogP	3.3 at 37℃ and pH7
CAS DataBase Reference	91161-71-6(CAS DataBase Reference)