Nicotinamide CAS#98-92-0

CAS Number: 98-92-0
Chemical Formula: C6H6N2O
Synonyms:

NIACINAMIDE USP GRANULAR
Nicotinamide,98%;Vitamin B3
Nicotinamidum

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Nicotinamide CAS#98-92-0

Nicotinamide aka Vitamin B3 (niacinamide, nicotinic acid amide) is the pyridine 3 carboxylic acid amide form of niacin. It is a water‑soluble vitamin that is not stored in the body. The main source of vitamin in diet is in the form of nicotinamide, nicotinic acid, and tryptophan. The main source of niacin include meat, liver, green leafy vegetables, wheat, oat, palm kernel oil, legumes, yeast, mushrooms, nuts, milk, fish, tea, and coffee.

The recommended daily dose of vitamin B3 in niacin equivalent is given in Table 1.
Nicotinamide is a component of coenzyme I (nicotinamide adenine dinucleotide, NADP) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP). The nicotinamide part of these two coenzyme structures in human body has reversible hydrogenation and dehydrogenation characteristics, It plays a hydrogen transfer role in biological oxidation, can promote tissue respiration, biological oxidation process and metabolism, and is of great significance to maintain the integrity of normal tissues, especially skin, digestive tract and nervous system. When lacking, pellagra is caused by the influence of cell respiration and metabolism.

Nicotinamide Chemical Properties

Melting point	128-131 °C(lit.)
Boiling point	150-160 °C
density	1.40
bulk density	360kg/m3
vapor density	4.22 (vs air)
vapor pressure	0Pa at 25℃
refractive index	1.4660 (estimate)
Fp	182 °C
storage temp.	2-8°C
solubility	691g/l
pka	3.3(at 20℃)
form	powder
color	white
PH	6.0-7.5 (50g/l, H2O, 20℃)
Odor	Odorless
PH Range	9
biological source	synthetic (organic)
Water Solubility	1000 g/L (20 ºC)
Decomposition	>=200 °C
Merck	14,6523
BRN	383619
BCS Class	1
Stability:	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	SMOOTHING
InChIKey	DFPAKSUCGFBDDF-UHFFFAOYSA-N
LogP	-0.38 at 21℃
CAS DataBase Reference	98-92-0(CAS DataBase Reference)
NIST Chemistry Reference	Niacinamide(98-92-0)
EPA Substance Registry System	Nicotinamide (98-92-0)

Safety Information

Hazard Codes	Xi,T,F
Risk Statements	36/37/38-39/23/24/25-23/24/25-11
Safety Statements	26-36-37/39-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
RTECS	QS3675000
F	8
Autoignition Temperature	480 °C
TSCA	TSCA listed
HS Code	29362990
Hazardous Substances Data	98-92-0(Hazardous Substances Data)
Toxicity	LD50 s.c. in rats: 1.68 g/kg (Brazda, Coulson)

Product Application of Nicotinamide CAS#98-92-0

Nicotinamide is a water-soluble B complex vitamin which is naturally present in animal products, whole cereals and legumes. Together with nicotinic acid (niacin), it belongs to vitamin B3 or vitamin PP, and is required as a nutrient to prevent the niacin deficiency disorder pellagra. It functions as a coenzyme or cosubstrate in many biological reduction and oxidation reactions required for energy metabolism in mammalian systems. It is used as a nutritional supplement, therapeutic agent, skin and hair conditioning agent in cosmetics, and a constituent of consumer household solvent and cleaning products and paints. Nicotinamide is approved for use by the FDA as a food additive to enrich corn meal, farina, rice, and macaroni and noodle products. It is also affirmed as GRAS (Generally Recognized as Safe) by the FDA as a direct human food ingredient which includes its use in infant formula. It is approved for use in pesticide products applied to growing crops only as a synergist with a maximum limitation of 0.5% of formulation.

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