5-ASA / Mesalamine CAS#89-57-6

CAS Number: 89-57-6
Chemical Formula: C7H7NO3
Synonyms:

5-Aminosalicylic acid, 98.5%, IKK inhibitor
2-HYDROXY-5-AMINOBENZOIC ACID
3-Carboxy-4-hydroxyaniline

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

5-ASA / Mesalamine CAS#89-57-6

Mesalamine is a monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position. It has a role as a non-steroidal anti-inflammatory drug. It is an aromatic amine, an amino acid, a member of phenols, a monocarboxylic acid and a monohydroxybenzoic acid. It is functionally related to a salicylic acid. It is a conjugate acid of a mesalaminate(1-).

5-Aminosalicylic acid Chemical Properties

Melting point	275-280 °C (dec.) (lit.)
Boiling point	276.03°C (rough estimate)
bulk density	300kg/m3
density	1.3585 (rough estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5500 (estimate)
Fp	279-281°C
storage temp.	2-8°C
solubility	Soluble in dimethyl sulfoxide.
pka	2.74, 5.84(at 25℃)
form	tablets
color	off-white to gray
PH	4.0-4.1 (0.8g/l, H2O, 20℃)
PH Range	Non-B uorescence (3.1) to light green B uorescence (4.4)
Water Solubility	<0.1 g/100 mL at 21 ºC
Decomposition	279-281 ºC
Merck	14,5904
BRN	2090421
BCS Class	4
Stability:	Stable. Incompatible with acids, acid anhydrides, acid chlorides, chloroformates, strong oxidizing agents.
Major Application	Detergent, hair dyes, prevention of colorectal cancer, treating inflammatory bowel disease, autoimmune disorders, gastrointestinal inflammation, chemokine-mediated diseases, mucosal tissue disorder, sleep disorders, rectoanal tenesmus, ulcerative colitis
InChI	1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)
InChIKey	KBOPZPXVLCULAV-UHFFFAOYSA-N
SMILES	Nc1ccc(O)c(c1)C(O)=O
LogP	0.98 at 25℃
CAS DataBase Reference	89-57-6(CAS DataBase Reference)
NIST Chemistry Reference	Mesalamine(89-57-6)
EPA Substance Registry System	Benzoic acid, 5-amino-2-hydroxy- (89-57-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-52/53
Safety Statements	26-36-24/25-61-37/39
WGK Germany	2
RTECS	VO1400000
F	8-10-23
Autoignition Temperature	280 °C
TSCA	TSCA listed
HazardClass	IRRITANT
HS Code	29225000
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3
Hazardous Substances Data	89-57-6(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 2800 mg/kg LD50 dermal Rat > 5000 mg/kg

Product Application of 5-ASA / Mesalamine CAS#89-57-6

5-Aminosalicylic acid (5-ASA) has been used to synthesize 5-formyl-aminosalicylate-inulin to quantify its release during in vitro digestion and fermentation and compare the in vitro fermentation properties of the conjugated inulin to native inulin. It is also used in cell adhesion assay to study its effects on E-cadherin glycosylation and membranous turnover. This compound is used to evaluate its effects on the neutrophilic inflammation index (NII) phenotype to study the effectiveness of the high cholesterol diet-gut inflammation (HCD-GI) platform. 5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

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