18-Crown-6 CAS#17455-13-9

CAS Number: 17455-13-9
Chemical Formula:C12H24O6
Synonyms:

JACS-17455-13-9
AKOS BBS-00004361
CROWN ETHER/18-CROWN-6

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

18-Crown-6 CAS#17455-13-9

18-Crown-6 is the simplest crown ether that can be prepared by reacting triethylene glycol with triethylene glycol dichloride in the presence of potassium hydroxide as a base. 18-Crown-6 can solubilize metal salts, particularly potassium salts, in nonpolar and dipolar aprotic solvents. Thus, it is widely used as a phase transfer catalyst. It can also be used as a metal complexing agent to prepare a variety of molecular complexes.

18-Crown-6 Chemical Properties

Melting point	42-45 °C(lit.)
Boiling point	116°C 0,2mm
density	1,175 g/cm3
refractive index	1.4580 (estimate)
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Methanol (Very Slightly)
form	Crystals or Crystalline Mass or Liquid
color	White or clear colorless
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
Merck	14,2602
BRN	1619616
Stability:	Stable. Incompatible with strong acids, strong oxidizing agents.
Cosmetics Ingredients Functions	NOT REPORTED
InChI	1S/C12H24O6/c1-2-14-5-6-16-9-10-18-12-11-17-8-7-15-4-3-13-1/h1-12H2
InChIKey	XEZNGIUYQVAUSS-UHFFFAOYSA-N
SMILES	O1CCOCCOCCOCCOCCOCC1
CAS DataBase Reference	17455-13-9(CAS DataBase Reference)
NIST Chemistry Reference	1,4,7,10,13,16-Hexaoxacyclooctadecane(17455-13-9)
EPA Substance Registry System	1,4,7,10,13,16-Hexaoxacyclooctadecane (17455-13-9)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-36-20/22-20/21/22
Safety Statements	26-36-39
RIDADR	2811
WGK Germany	3
RTECS	MP4500000
F	10
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
HS Code	29329995
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral
Toxicity	LD50 orally in Rabbit: 525 mg/kg LD50 dermal Rabbit 3888 mg/kg

Product Application of 18-Crown-6 CAS#17455-13-9

18-Crown-6 is used as an efficient phase transfer catalyst and as a complexing agent with a variety of small cation. It is involved in the synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6. It facilitates the solubility of potassium permanganate in benzene, which is used for oxidizing the organic compounds. It is used to accelerate various substitution reactions as well as enhances the power of nucleophiles such as potassium acetate. It is utilized in the alkylation reactions in the presence of potassium carbonate, N-alkylation of glutarimide and succinimide with dimethylcarbonate. The complex formed by its reaction with potassium cyanide acts as a catalyst in the cyanosilylation of aldehydes, ketones and quinines with trimethylsilyl cyanide (TMSCN).

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