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Shikimic acid CAS#138-59-0
CAS Number: 138-59-0
Chemical Formula: C7H10O5
Synonyms:
L-SHIKIMIC ACID
(3R,4S,5R)-3,4,5-TRIHYDROXY-1-CYCLOHEXENECARBOXYLIC ACID
R(3R,4S,5R)-()-3,4,5-Trihydroxy-1-cyclohexenecarboxylic acid
Appearance: White powder
HS Code:29181980
MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)
Products Description of Shikimic acid CAS#138-59-0
Shikimic acid is a white crystalline powder that is easily soluble in water. It is named after the Japanese shikigrass from which it was first isolated. It is an important metabolite of plants and microorganisms. For a long time, shikimic acid has been mainly extracted from the dried mature fruits of the Illicium or Japanese shikigrass (Japanese aniseed) of the Illicium family. In recent years, there have also been reports on the extraction of shikimic acid from the fruits of Liquidambar formosana and pine needles.
Parameters
| Melting point | 185-187 °C (lit.) |
| alpha | -180 º (c=4, H2O 25 ºC) |
| Boiling point | 225.11°C (rough estimate) |
| density | 1.52 g/cm3 (27.2℃) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | -180 ° (C=1, H2O) |
| storage temp. | 2-8°C |
| solubility | 180g/l |
| form | Powder |
| pka | pK (14.1°) 5.19 |
| color | White to light beige or light gray |
| optical activity | [α]/D -180.0±5.0°, c = 4 in H2O |
| Water Solubility | 18 g/100 mL (20 ºC) |
| Sensitive | Hygroscopic |
| Merck | 148480 |
| BRN | 4782717 |
| InChIKey | JXOHGGNKMLTUBP-HSUXUTPPSA-N |
| LogP | -1.5 at 21℃ and pH1 |
| Surface tension | 49.86mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 138-59-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Shikimic acid(138-59-0) |
| IARC | 3 (Vol. 40, Sup 7) 1987 |
| Safety Information | |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | GW4600000 |
| F | 45726 |
| HS Code | 29181980 |
| Hazardous Substances Data | 138-59-0(Hazardous Substances Data) |
| Toxicity | LD5 i.p. in mice: 1000 mg/kg (Evans, Osman) |
Product Application of Shikimic acid CAS#138-59-0
Shikimic acid is a key precursor for the synthesis of many alkaloids, aromatic amino acids, indole derivatives and chiral drugs. Recently, shikimic acid has been used as a starting material for oseltamivir (the active ingredient of Tamiflu), a neuraminidase inhibitor that can be used to treat and prevent influenza A and influenza B.
It is an anti-tumor drug and also a synthetic raw material for anti-tumor drugs such as dioxins and glyoxalase inhibitors
It is used as a standard for the quantitative determination of shikimic acid content in the apical part of the root. It is also used as a substrate for shikimic acid kinase assay.
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