Arbutin CAS#497-76-7

Products Description of Arbutin CAS#497-76-7

Arbutin is a glycosylated hydroquinone that has been found in Arctostaphylos plants and has diverse biological activities, including tyrosinase inhibitory, antioxidant, and anti-inflammatory properties. It inhibits human tyrosinase activity in crude tyrosinase solution isolated from human melanocytes (IC50s = 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM). Arbutin (50 μM) inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes and inhibits AAPH-induced decreases in cell viability in cultured human skin fibroblasts when used at concentrations greater than 125 μM. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) prevents increases in IL-1β, IL-6, and TNF-α levels in lung tissue and serum. Formulations containing arbutin have been used in the treatment of hyperpigmentation disorders.

Parameters

Melting point	195-198 °C
alpha	-64 º (c=3)
Boiling point	375.31°C (rough estimate)
density	1.3582 (rough estimate)
refractive index	-65.5 ° (C=4, H2O)
storage temp.	Inert atmosphere,Room Temperature
solubility	H2O: 50 mg/mL hot, clear
form	Solid
pka	10.10±0.15(Predicted)
color	White
optical activity	[α]/D -64.0±2.0°, c = 3 in H2O
biological source	synthetic or plant
Water Solubility	10-15 g/100 mL at 20 ºC
Sensitive	Hygroscopic
Merck	14,773
BRN	89673
Stability:	Stable. Hygroscopic - store under dry nitrogen.
InChIKey	BJRNKVDFDLYUGJ-RMPHRYRLSA-N
LogP	-1.350
CAS DataBase  Reference	497-76-7(CAS DataBase Reference)
EPA Substance  Registry System	.beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
RTECS	CE8863000
F	3-10-23
HS Code	29389090
Hazardous  Substances Data	497-76-7(Hazardous Substances Data)

Product Application of  Arbutin CAS#497-76-7

Diuretic and anti-infective drugs of urinary system. Color photographic developing stabilizer. Whitening, anti-freckle, hair care in cosmetics.

Factory and Equipment Show

Fast delivery time

Inventory 2-3 working days New production 7-10 working days