Aminophylline CAS#317-34-0

CAS Number: 317-34-0
Chemical Formula: C9H16N6O2
Synonyms:

AMinophylline(Phyllocontin, Truphylline)
Theophylline-ethylenediaMine anhydrous COS
THEOPHYLLINE COMPOUND WITH ETHYLENEDIAMINE

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Aminophylline CAS#317-34-0

Aminophylline is a drug combination consisting of bronchodilator theophylline and ethylenediamine in 2: 1 ratio. It is a kind of non-selective adenosine receptor blocker, histone deacetylase activator and phosphodiesterase inhibition. It is mainly indicated for the treatment of various kinds of lung diseases including asthma, COPD, chronic bronchitis and emphysema. Aminophylline exerts its effect through the component of theophylline in vivo. Theophylline can relax the smooth muscle of the bronchial airways and pulmonary blood vessels. It can competitively inhibits type III and type IV phosphodiesterase (PDE), which breaks down cyclic AMP in smooth muscle cells, possibly leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor to block the adenosine mediated bronchoconstriction. Furthermore, during the inflammatory states, theophylline can activate the histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones to initiate the transcription.

Aminophylline Chemical Properties

Melting point	269-270 °C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	H2O: 3.7 mg/mL solutions should be freshly prepared.
pka	pKa 5.0 (Uncertain)
form	powder
color	white to off-white
Water Solubility	soluble
Merck	14,465
Cosmetics Ingredients Functions	SKIN CONDITIONING SURFACTANT - CLEANSING
InChI	InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2
InChIKey	LHRHXWBJUQKYEL-UHFFFAOYSA-N
SMILES	O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN
LogP	-0.175 (est)
CAS DataBase Reference	317-34-0(CAS DataBase Reference)
EPA Substance Registry System	1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0)

Safety Information

Hazard Codes	Xn,C
Risk Statements	22-42/43-34-36/37/38-20/21/22
Safety Statements	45-36/37/39-26-23-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	XH5600000
F	10-23
TSCA	TSCA listed
HazardClass	6.1(b)
PackingGroup	III
HS Code	29339900
Hazardous Substances Data	317-34-0(Hazardous Substances Data)
Toxicity	LD50 orally in mice: 540 mg/kg (Thompson, Warren)

Product Application Of Aminophylline CAS#317-34-0

Aminophylline exhibits vasodilatory and anti-inflammatory activity and is occasionally clinically used to treat chronic obstructive pulmonary disorder (COPD). In animal models of allergen-induced lung inflammation, aminophylline decreases levels of IL-5, IL-8, and eosinophils. It is mostly used to prepare solutions for intravenous injections.

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