8-Hydroxyquinoline CAS#148-24-3

CAS Number: 148-24-3
Chemical Formula: C9H7NO
Synonyms:

8-hydroxy-quinolin
8-OQ
8-Oxyquinolin

Appearance: Transperant Liquid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

8-Hydroxyquinoline CAS#148-24-3

8-Hydroxyquinoline is a white to cream-colored crystal or crystalline powder that is insoluble in water or ether and freely soluble in ethanol, acetone, chloroform, benzene, and aqueous mineral acids. It readily forms stable metal chelates, which are soluble or precipitable in organic solvents, depending on the pH of the solution (Hollingshead, 1954).8-Hydroxyquinoline is a monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes. It has a role as an antibacterial agent, an iron chelator, an antiseptic drug and an antifungal agrochemical. It derives from a hydride of a quinoline.

8-Hydroxyquinoline Chemical Properties

Melting point	70-73 °C(lit.)
Boiling point	267 °C752 mm Hg(lit.)
density	1.0340
vapor pressure	0.221Pa at 25℃
refractive index	1.4500 (estimate)
Fp	267°C
storage temp.	Store below +30°C.
solubility	0.56g/l
form	Liquid
pka	5.017(at 20℃)
color	White to pale yellow or light beige
Water Solubility	INSOLUBLE
Sensitive	Light Sensitive
Merck	14,4843
BRN	114512
Cosmetics Ingredients Functions	ANTIMICROBIAL CHELATING
InChIKey	MCJGNVYPOGVAJF-UHFFFAOYSA-N
LogP	1.85 at 25℃
CAS DataBase Reference	148-24-3(CAS DataBase Reference)
IARC	3 (Vol. 13, Sup 7) 1987
NIST Chemistry Reference	8-Quinolinol(148-24-3)
EPA Substance Registry System	8-Quinolinol (148-24-3)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-68-36/37/38
Safety Statements	45-36/37/39-26-36
RIDADR	2811
WGK Germany	3
RTECS	VC4200000
Hazard Note	Harmful/Irritant
TSCA	TSCA listed
HazardClass	9
PackingGroup	III
HS Code	29334990
Hazardous Substances Data	148-24-3(Hazardous Substances Data)
Toxicity	An LD50 value of 1,200mg/kg was reported for oral administration of 8-hydroxyquinoline to rats (straidsex unspecified; AAPCO, 1966);a value of 48 mg/kg was reported for intraperitoneal administration to mice (strain/sex unspecxed; Bernstein et al., 1963).

Product Application of 8-Hydroxyquinoline CAS#148-24-3

8-Hydroxyquinoline (8HQ) is an intermediate of halogenated quinoline anti-amebic drugs, including quiniodoform, clioquinoline, diiodoquinoline and the like. These drugs exert anti-amebic effects by inhibiting intestinal commensal bacteria, and are effective against amoebic dysentery, but have no effect on extra-intestinal amoebic parasites.8HQ is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities.

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