4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy CAS#2226-96-2

CAS Number: 2226-96-2
Chemical Formula: C9H18NO2*
Synonyms:

HYDROXY-TEMPO
4-HYDROXY-2,2,6,6-TETRAMETHYL-PIPERIDINOOXY
4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINYLOXY

Appearance: Orange Solid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy CAS#2226-96-2

TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy.

4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Chemical Properties

Melting point	69-71 °C(lit.)
Boiling point	302.58°C (rough estimate)
density	1.0402 (rough estimate)
vapor pressure	0.025Pa at 20℃
refractive index	1.4350 (estimate)
Fp	146°(295°F)
storage temp.	2-8°C
solubility	1670g/l
pka	5.07[at 20 ℃]
form	Crystals or Crystalline Powder
color	Orange
PH	8.2 (20g/l, H2O, 20℃)
Water Solubility	soluble
Merck	14,9141
BRN	1422990
Stability:	Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions	ANTIOXIDANT
InChI	1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
InChIKey	FAPCFNWEPHTUQK-UHFFFAOYSA-N
SMILES	CC1(C)CC(O)CC(C)(C)N1[O]
LogP	0.56 at 25℃
CAS DataBase Reference	2226-96-2(CAS DataBase Reference)
NIST Chemistry Reference	1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-(2226-96-2)
EPA Substance Registry System	1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl- (2226-96-2)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-36/38
Safety Statements	26-36-37/39-36/37/39-27
WGK Germany	1
RTECS	TN8991000
Autoignition Temperature	260°C (DIN 51794)
TSCA	TSCA listed
HS Code	29333999
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 STOT RE 2 Oral
Hazardous Substances Data	2226-96-2(Hazardous Substances Data)
Toxicity	LD50 oral in rat: 1053mg/kg

Product Application Of 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy CAS#2226-96-2

In biochemical research, 4-hydroxy-TEMPO has been investigated as an agent for limiting reactive oxygen species. It catalyzes the disproportionation of superoxide, facilitates hydrogen peroxide metabolism, and inhibits Fenton chemistry.4-Hydroxy-TEMPO, along with related nitroxides, are being studied for their potential antioxidant properties.On an industrial-scale 4-hydroxy-TEMPO is often present as a structural element in hindered amine light stabilizers, which are commonly used stabilizers in plastics, it is also used as a polymerisation inhibitor, particularly during the purification of styrene.

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