2,2,2-Trifluoroethanol CAS#75-89-8

CAS Number: 75-89-8
Chemical Formula: C2H3F3O
Synonyms:

1,2,2-trifluoroethan-1-ol
2,2,2-TRIFLUOROETHANOL-D3, HIGH ENRICHMENT
2,2,2-Trifluoroethan-1-ol 99%

Appearance: Transperant Liquid

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

2,2,2-Trifluoroethanol CAS#75-89-8

2,2,2-trifluoroethanol or trifluoroethanol is called TFEA or TEF, it is important intermediate of the fluorine-containing aliphatic, it is colorless, it is miscible liquids with water, it has similar odor with ethanol. Due to the strong electron-withdrawing effect of trifluoromethyl, acid of trifluoromethyl is stronger than ethanol, it can generate hydrogen-bonded stable complex (such as: tetrahydrofuran, pyridine) with heterocyclic compound. Due to this unique physical and chemical properties and special molecular structure, it has different performance with other alcohols, it can participate in a variety of organic reactions, it can be oxidized to acetaldehyde trifluoromethyl or trifluoroacetic acid, it can also provide trifluoromethyl, it can participate in the Still-Gennari improvements of Horner-Wadsworth-Emmons reaction. It has wide range of uses in medicine, pesticides, dyes, energy, and other aspects of organic synthesis.

2,2,2-Trifluoroethanol Chemical Properties

Melting point	−44 °C(lit.)
Boiling point	77-80 °C(lit.)
density	1.391 g/mL at 20 °C
vapor density	3.5 (vs air)
vapor pressure	70 mm Hg ( 25 °C)
refractive index	n20/D 1.3(lit.)
Fp	85 °F
storage temp.	Store below +30°C.
solubility	soluble in Chloroform, Methanol
form	Liquid
pka	12.4(at 25℃)
color	Clear colorless
Specific Gravity	1.373
Odor	Alcoholic odour
PH	7
PH Range	5-7 (10% aq soln)
biological source	goat
explosive limit	8.4-28.8%(V)
Water Solubility	Miscible with water, ethers, ketones, alcohols and chloroform.
λmax	λ: 260 nm Amax: ≤0.03 λ: 280 nm Amax: ≤0.02
Merck	14,9682
BRN	1733203
Dielectric constant	8.5500000000000007
Stability:	Stable. Flammable - note wide explosion limits. Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, sodium, potassium.
InChIKey	RHQDFWAXVIIEBN-UHFFFAOYSA-N
CAS DataBase Reference	75-89-8(CAS DataBase Reference)
NIST Chemistry Reference	Ethanol, 2,2,2-trifluoro-(75-89-8)
EPA Substance Registry System	2,2,2-Trifluoroethanol (75-89-8)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	10-20/21/22-37/38-41-62-38-36/37/38
Safety Statements	26-36-39-45-36/37/39-16
RIDADR	UN 1986 3/PG 3
WGK Germany	1
RTECS	KM5250000
Autoignition Temperature	~896 °F
Hazard Note	Flammable/Toxic
TSCA	TSCA listed
HazardClass	3
PackingGroup	III
HS Code	29055910
Toxicity	LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rat 1680 mg/kg

Product Application of 2,2,2-Trifluoroethanol CAS#75-89-8

(1) It can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, synthetic narcotics fluoride ether (Fluroxene), isoflurane (Isoflurane) and to chlorine halothane (Desflurane), central nervous system stimulants fluticasone Seoul (Flowotyl), proton pump inhibitor lansoprazole (Lansoprazol, pp inhibitors), anti-arrhythmic drugs flecainide with amine (Flecamide), analgesics, benzodiazepines (Quazepam), difficulty urinating therapeutic drug KMD-3213, herbicide trifluoromethyl thiomethyl (Triflusulfuronmethyl).
(2) It can be used for chemical reagents.
(3) It can be used as solvent, it can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, it can be also used as pharmaceutical, pesticide intermediates.
(4) It can be used as solvent, it is also used as medicine, pesticide intermediates.

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