Clotrimazole CAS#23593-75-1

CAS Number: 23593-75-1
Chemical Formula: C22H17ClN2
Synonyms:

myclo
(2-Chlorophenyl)diphenyl-1-imidazolylmethane
1-(o-Chloro-α,α-diphenylbenzyl)imidazole

Appearance: White Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Product Details

Clotrimazole CAS#23593-75-1

Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and, like other imidazoles, disturbs the fungal cell membrane. In mammalian cells, clotrimazole potently inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 μM, respectively).

Clotrimazole Chemical Properties

Melting point	147-149°C
Boiling point	501.14°C (rough estimate)
density	1.1095 (rough estimate)
refractive index	1.5940 (estimate)
storage temp.	2-8°C
solubility	Soluble in chloroform, DMSO, DMF and alcohols
pka	pKa 4.7(EtOH 50%aq ) (Uncertain)
form	Solid
color	White to Almost white
Water Solubility	<10mg/L(25 ºC)
λmax	556nm(Phosphate buffer sol.)(lit.)
Merck	14,2417
Major Application	pharmaceutical pharmaceutical small molecule
Cosmetics Ingredients Functions	ANTIMICROBIAL ANTI-SEBORRHEIC
InChI	InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey	VNFPBHJOKIVQEB-UHFFFAOYSA-N
SMILES	C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
NIST Chemistry Reference	Clotrimazole(23593-75-1)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/38
Safety Statements	26-36
WGK Germany	3
RTECS	NI4377000
HS Code	29332900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Irrit. 2
Hazardous Substances Data	23593-75-1(Hazardous Substances Data)
Toxicity	LD50 in male mice, rats (mg/kg): 923, 708 orally (Tettenborn)

Product Application Of Clotrimazole CAS#23593-75-1

Clinical topical usage of 1% clotrimazole cream or solution for treating candidiasis ringworm, tinea versicolor, athlete's foot, nail ringworm and other skin infections. Clotrimazole vaginal tablets (100mg) administration can be used for treating candidiasis and trichomoniasis vaginal infections. Side effects include local irritation and burning sensations. Oral administration can be used for the treatment of deep fungal infection but with serious side effects such as gastrointestinal irritation, neutropenia, and liver function abnormalities.
1. Oral administration: (1) can be used for the treatment of oropharyngeal candidiasis. (2) it can also be used for chemotherapy and the prevention of the oropharynegeal candidiasis infection of immunocompromised or defect patients.
2. Topical: (1) skin candidiasis. (2) Tinea, jork itch and ringworm caused by Trichophyton, Epidermophyton and small spores; tinea versicolor caused by Pityrosporum.
3. Vaginal administration: (1) Vaginitis induced by Candida or other fungi. (2) vaginal infection caused by yeast. (3) Vagina super-infection caused by susceptible strains of the drug.
The above information is edited by the chemicalbook of Dai Xiongfeng.

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