Silybin CAS#22888-70-6

Products Description of Silybin CAS#22888-70-6

Silybin, also known as silibinin, is the principal biologically active constituent of the silymarin complex (about 70–80%) and is a mixture of silybin A and silybin B. Pharmacological research demonstrated that silybin has shown pleiotropic biological properties, including potent antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial and immunosuppressive activities. 

Parameters

Melting point	164-174°C
alpha	D20 +11° (c = 0.25 in acetone + alcohol)
Boiling point	793.0±60.0 °C(Predicted)
density	1.527±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Acetone (Sparingly), DMSO, Methano (Sparingly)
form	Solid
pka	pKa 6.42±0.04 (Uncertain)
color	Pale Yellow
Water Solubility	54mg/L(24.99 ºC)
Merck	13,8607
Stability:	Stable. Incompatible with strong oxidizing agents, strong bases.
LogP	4.232 (est)
CAS DataBase  Reference	22888-70-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39-24/25-22-36
RIDADR	3172
WGK Germany	3
RTECS	DJ2981770
HS Code	29329990
Toxicity	LD50 intravenous in mouse: 1056mg/kg

Product Application of  Silybin CAS#22888-70-6

Silibinin has been used:

To study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR)

To study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay

To examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing

To study its inhibitory effect on Escherichia coli ATP synthase

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